Infection and Immune Aging in Older Adults: A Look at How Immunosenescence Relates to Infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational cohort will collect clinical data and multiple biological samples from older adults, including blood, urine, stool, sputum, and nasopharyngeal swabs. Researchers will track infection events, health status, and aging-related characteristics over time. The study will analyze immune cell changes, immune receptor patterns, epigenetic marks, metabolic profiles, and microbiota to identify biomarkers linked to immunosenescence and infection susceptibility through integrated clinical and multi-omics data.

Why it matters

Who can join: the full rules

Inclusion Criteria for the Healthy Control Group

1. No clinical symptoms suggestive of infection, including fever, cough, dyspnea, fatigue, or myalgia.
2. No abnormal physical signs, including lymphadenopathy, hepatomegaly, splenomegaly, or skin rash.
3. Normal laboratory test results, including complete blood count (CBC), C-reactive protein (CRP), and liver and renal function tests.
4. Healthy adults without underlying chronic diseases, no history of infectious diseases within the previous 6 months, and generally normal cognitive function.
5. Male or female.
6. Able to understand the study procedures and voluntarily provide written informed consent.

Inclusion Criteria for the Infection Group 1.Age: 60 years or older; no gender restrictions. 2. Clinically diagnosed with an infectious disease by the treating physician. 3. The participant provides informed consent and signs the relevant documents.

\-------------- Exclusion Criteria for the Healthy Control Group

1. Refusal to participate in the study;
2. Any other condition that, in the opinion of the investigator, makes the participant unsuitable for enrollment.

Exclusion Criteria for the Infection Group

1. Final primary diagnosis is a non-infectious disease (e.g., connective tissue disease, tumor, or other conditions).
2. Positive culture results are determined by the clinician to be due to colonization or contamination rather than infection.
3. Refusal to participate in the study.
4. Patients in critical or severe conditions who are unable to cooperate with sample collection.
5. Other conditions deemed unsuitable for inclusion as determined by the researchers.

Where it's running

• Huashan Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Jingwen Ai, MD
• Email: jingwenai1990@126.com
• Phone: 86+13764990804

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.