Influenza Vaccine Immunogenicity in Older Adults with Repeated Vaccination

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 4 trial compares three influenza vaccine formulations—standard dose, MF59 adjuvanted, and high dose—in adults 65 years and older. A younger reference group (19–49 years) receiving standard-dose vaccine helps contextualize age-related differences. Participants will receive a vaccine and provide blood samples to measure immune responses over time. The study aims to understand how immune aging and repeated vaccination influence immunogenicity across formulations. Exclusion criteria include recent vaccination, immunocompromising conditions, and any contraindication to vaccination.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Older adult group: aged 65 years or older
* Younger reference group: aged 19 to 49 years
* Able to receive influenza vaccination and complete the scheduled follow up

Exclusion Criteria:

* Receipt of an influenza vaccine or any other vaccine within 4 weeks prior to enrollment
* Immunocompromised status, including ongoing chemotherapy or immunosuppressive therapy, high dose corticosteroid therapy, history of solid organ or hematopoietic stem cell transplantation, active malignancy, HIV infection, or other clinically significant immunocompromising conditions
* Moderate or severe acute infection
* History of allergic reaction to an influenza vaccine or any of its components, or any other condition that precludes influenza vaccination
* Inability, as determined by the investigator, to understand the purpose and procedures of the study and provide voluntary informed consent

Where it's running

• Korea University Guro Hospital
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Min Joo Choi, MD, PhD
• Email: cowgow9696@gmail.com
• Phone: 82-2-2626-3053

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.