Increasing dietary fiber intake before colorectal cancer surgery
FiberUP in Clinical Practice: Increasing Preoperative Dietary Fiber Intake in Colorectal Cancer Patients.
This study is testing if increasing fiber in the diet before surgery can help people with colorectal cancer recover better and have fewer complications.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 54 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Wageningen University Academic / other |
| Locations | 3 sites (Arnhem, Gelderland and 2 other locations) |
| Trial ID | NCT06212817 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial aims to explore the feasibility of enhancing preoperative dietary fiber intake in patients diagnosed with colorectal cancer who are scheduled for surgery. Participants will be divided into three groups: one receiving personalized dietary advice through the Vezel-UP tool, another consuming a vegetable product rich in natural fibers, and a control group maintaining their habitual diet. The study will assess the impact of these interventions on postoperative complications, which can significantly affect recovery and quality of life. The intervention period will last approximately four weeks, varying based on individual patient characteristics.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older diagnosed with colorectal cancer who are scheduled for elective tumor resection.
Not a fit: Patients with prior large abdominal resections, inflammatory bowel diseases, or those currently on strict diets may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could reduce postoperative complications and improve recovery outcomes for colorectal cancer patients.
How similar studies have performed: Previous studies have indicated a potential link between higher dietary fiber intake and reduced postoperative complications, suggesting this approach may be promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years; * Being diagnosed with CRC and planned to undergo elective CRC resection; Exclusion Criteria: * Previously have had a large abdominal resection, excluding appendectomy and cholecystectomy; * Diagnosed with Crohn's disease, Ulcerative Colitis, Celiac Disease; * Currently having a stoma; * Known allergic reactions to plants from the Asteraceae (Compositae) family (e.g., lettuce, daisies, sunflowers, artichokes, sage, tarragon, chamomile, chicory etc.); * Currently following a strict diet and unwilling or unable to change (e.g., gluten free or ketogenic diet); * Currently using fiber supplements, prebiotics and/or probiotics and unwilling to stop using these for the duration of the intervention; * Having a habitual dietary fiber intake \>30 g/day for women and \>40 g/day for men, measured with a food frequency questionnaire; * Dementia or other cognitive disabilities that makes it impossible to fill out questionnaires correctly; * Illiteracy (inability to read and understand Dutch).
Where this trial is running
Arnhem, Gelderland and 2 other locations
- Rijnstate — Arnhem, Gelderland, Netherlands (Recruiting)
- Ziekenhuis Gelderse Vallei — Ede, Gelderland, Netherlands (Recruiting)
- Meander Medisch Centrum — Amersfoort, Utrecht, Netherlands (Recruiting)
Study contacts
- Study coordinator: Niels Klaassen, MSc
- Email: niels.klaassen@wur.nl
- Phone: + 31 (0) 317 487 265
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.