Improving oxygen care for ICU patients on ventilators
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
This study tests if teaching hospital staff to keep oxygen levels between 90-96% for patients on ventilators can help them recover faster and stay on the ventilator for less time.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 3600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Colorado, Denver Academic / other |
| Locations | 1 site (Aurora, Colorado) |
| Trial ID | NCT06501118 on ClinicalTrials.gov |
What this trial studies
This project implements a targeted oxygen saturation range of 90-96% for adult patients on mechanical ventilation through a multimodal educational intervention. It utilizes a multi-hospital, cluster randomized approach to enhance adherence to this oxygen target. The intervention is rolled out in phases across different hospital ICUs, with staff education and real-time informatics tools provided to improve implementation. The study aims to reduce ventilator length of stay and prevent occult hypoxemia in critically ill patients.
Who should consider this trial
Good fit: Ideal candidates include adult patients admitted to the ICU who require invasive mechanical ventilation.
Not a fit: Patients who may not benefit include those with pre-existing conditions requiring chronic positive pressure ventilation or those transferred from outside the UCHealth system.
Why it matters
Potential benefit: If successful, this approach could lead to shorter ventilator stays and improved oxygen management for critically ill patients.
How similar studies have performed: Other studies have shown success with educational interventions aimed at optimizing care in ICU settings, suggesting this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Admission to ICU and requiring invasive mechanical ventilation Exclusion Criteria: * Transferred patients from outside the UCHealth system\*: * Patients with pre-existing disease that requires chronic use of positive pressure ventilation delivered through a tracheostomy\*: * Pregnant women: * Prisoners * Patients receiving mechanical ventilation for less than twelve hours
Where this trial is running
Aurora, Colorado
- University of Colorado — Aurora, Colorado, United States (Recruiting)
Study contacts
- Principal investigator: Neil Aggarwal, MD — University of Colorado, Denver
- Study coordinator: Carrie Higgins, BSN
- Email: carrie.higgins@cuanschutz.edu
- Phone: 720-560-3037
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.