Improving medication adherence in patients with uncontrolled hypertension using urine tests

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to address the issue of medication non-adherence in patients with poorly controlled hypertension by utilizing urine mass spectrometry to assess adherence to antihypertensive medications. The approach involves a three-step process: first, a retrospective analysis of medication adherence in patients recently admitted for stroke; second, a prospective recruitment of participants with uncontrolled hypertension; and third, counseling for those identified as non-adherent, followed by reassessment of their medication adherence and blood pressure levels. This method is convenient, non-invasive, and cost-effective, making it suitable for clinical settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age of 21 - 80 years
2. Systolic blood pressure of ≥140 mmHg or average systolic blood pressure ≥135 mmHg, or diastolic blood pressure ≥90 mmHg or average diastolic blood pressure ≥85 mmHg, on at least two measurements
3. Currently taking 2 or more hypertension medications
4. Able to provide informed consent.

Exclusion Criteria:

* Significant kidney impairment with eGFR of less than 45mL/min/1.73m2 or on dialysis
* Known history of chronic liver disease

Where it's running

• Changi General Hospital
  Singapore, Singapore Recruiting

Study contacts

• Study coordinator: Sumitro Harjanto, MD MRCP
• Email: sumitro.harjanto@singhealth.com.sg
• Phone: +6564267818

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.