Iloperidone for adults with uncontrolled high blood pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, randomized, double-blind, placebo-controlled Phase 2 study comparing iloperidone to placebo in adults with uncontrolled hypertension. Eligible participants must have a seated systolic blood pressure ≥130 mmHg despite more than 8 weeks of one or more antihypertensive therapies. Participants with confirmed severe (grade 3) hypertension, unstable cardiac disease, or renal insufficiency are excluded. The trial is sponsored by Vanda Pharmaceuticals and will run at Vanda investigative sites in Phoenix, Tempe, and Tucson, Arizona.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* SiSBP \>/= 130 mmHg despite \>8 weeks treatment w/ 1 or more antihypertensive therapies

Exclusion Criteria:

* Confirmed Grade 3/severe hypertension (SiSBP \>/= 180 mmHg, SiDBP \>/= 120 mmHg), unstable cardiac disease, renal insufficiency

Where it's running

• Vanda Investigative Site
  Tempe, Arizona, United States Recruiting
• Vanda Investigative Site
  Chula Vista, California, United States Recruiting
• Vanda Investigative Site
  Dublin, California, United States Recruiting
• Vanda Investigative Site
  Walnut Creek, California, United States Recruiting
• Vanda Investigative Site
  Fort Myers, Florida, United States Recruiting
• Vanda Investigative Site
  Columbus, Georgia, United States Recruiting

Study contacts

• Study coordinator: Vanda Pharmaceuticals, Inc.
• Email: clinicaltrials@vandapharma.com
• Phone: 202-734-3400

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.