Improving gait in Parkinson's disease using variable frequency stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of Variable Frequency Stimulation (VFS) in patients with Parkinson's disease who have undergone Deep Brain Stimulation (DBS). It is a randomized, controlled, double-blinded crossover study focusing on various programming strategies of VFS to determine which is most effective in improving gait and balance disorders. Participants will be monitored over a 4-month period to assess the long-term benefits of the chosen programming strategy. The goal is to gather clinical evidence that can inform future applications of VFS in treating gait impairments associated with Parkinson's disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Idiopathic Parkinson's disease (according to the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease);
* 18-75 years of age;
* Hoehn \& Yahr ≤ 3 (in best OFF-medication condition)；
* Implanted bilateral subthalamic nucleus DBS for over 1 year；
* gait Impairments in OFF-medication condition；
* High Frequency Stimulation provides significant improvement；
* in OFF-medication On-stimulation condition, capable of walking ≥ 10m.

Exclusion Criteria:

* mental disorder or dementia;
* Pregnant women, lactating mothers or women who are unable to take effective measures to prevent pregnancy;
* With other diseases that can affect walking distance, such as joint diseases of the lower body, spinal diseases, neuropathy, or serious heart or lung diseases;
* In severe health condition, such as diseases associated with heart or liver;
* Epilepsy;
* Lead off target;
* Unable to willingly sign Written informed Consent;
* Disagree or unable to cooperate with follow-up sessions.

Where it's running

• Peking Union Medical College Hospital
  Beijing, China Recruiting

Study contacts

• Principal investigator: Yi Guo, M.D. — Peking Union Medical College Hospital
• Study coordinator: Yi Guo, M.D.
• Email: guoyi@pumch.cn
• Phone: 13910091280

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How aerobic exercise (forced vs voluntary cycling) affects movement, thinking, and brain signals in people with Parkinson’s and deep brain stimulation

  This study tests whether forced or voluntary cycling improves movement, thinking, and brain activity in people with Parkinson’s who already have a DBS device.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT07442747

• Deep brain stimulator battery replacement for people with Parkinson's disease

  This trial tests whether having a DBS battery replacement under regional chest-wall nerve blocks works as well and is as safe as having it under general anesthesia for people with Parkinson's disease aged 40–85.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07176494

• Understanding brain connectivity in Parkinson's disease and deep brain stimulation

  This study is trying to see how deep brain stimulation affects brain connections in people with Parkinson's disease to improve their treatment and help with movement and thinking.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05568199

• Ginger as a Modifier of Ghrelin Levels in Parkinson’s Disease and REM Sleep Behavior Disorder

  This study tests whether ginger capsules can raise ghrelin levels in people with Parkinson’s disease, REM sleep behavior disorder, and healthy controls.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT07882108

• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

  This study tests whether MAVEN can match the recording data collected during DBS surgery for movement disorders using standard equipment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07868614

• Mental imagery with self-regulation to help daily activities in Parkinson's disease

  This study tests whether a six-week program of mental imagery combined with self-regulation can help people with Parkinson’s perform daily activities better than standard learning or exercise.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07860294

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.