Impact of pEEG Monitoring on Delirium and Ventilator Days in ICU Patients
Continuous Processed Neurological Monitor to Guide the Management of Sedation for Patients Receiving Mechanical Ventilation: a Prospective Observational Study to Test the Effects on Delirium, Days on a Ventilator, and Post-Intensive Care Syndrome.
This study is testing if using a special brain monitoring tool can help reduce confusion and the time on a breathing machine for adults in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 17 Years to 110 Years |
| Sex | All |
| Sponsor | Fraser Health Academic / other |
| Locations | 1 site (Abbotsford, British Columbia) |
| Trial ID | NCT06019078 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare the rates of delirium, duration of mechanical ventilation, and incidence of Post Intensive Care Syndrome (PICS) in adult ICU patients. It will evaluate patients whose sedation and analgesia are managed using both the Richmond Agitation and Sedation Scale (RASS) and Processed Electroencephalography (pEEG) monitoring against those managed with RASS alone. Participants will be monitored during their ICU stay and assessed for PICS at discharge and follow-up intervals. The study seeks to determine if the addition of pEEG monitoring can improve patient outcomes in critically ill individuals.
Who should consider this trial
Good fit: Ideal candidates are adults aged 17 years and older who are admitted to the ICU and require mechanical ventilation with IV sedation or analgesia.
Not a fit: Patients who are intubated at a non-participating hospital or those who cannot provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to reduced delirium days and shorter mechanical ventilation durations for ICU patients.
How similar studies have performed: While the use of pEEG monitoring in sedation management is a relatively novel approach, similar studies have shown promising results in improving patient outcomes in critical care settings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Admitted to ICU 2. Receive mechanical ventilator support during ICU stay 3. Require IV sedation or analgesic while ventilated 4. Discharged home from the hospital 5. Use of pEEG for sedation or analgesic titration 6. Able to read and speak English 7. Mechanically ventilated greater than 48 hours 8. Aged 17 years +1 day or greater 9. Consent to participate 10. Participants need a computer with a keyboard, internet access, and email access for the questionnaires and assessment and be able to use computer and internet. Exclusion Criteria: 1. Deceased during hospitalization 2. Intubated at a hospital not included within the study \> 12 hours 3. Discharge to rehabilitation facility, long term care, or other outpatient setting 4. Inability to provide informed consent 5. Currently enrolled in any other research study involving drugs or devices 6. Is unable to be screened for delirium during ICU admission.
Where this trial is running
Abbotsford, British Columbia
- Abbotsford Regional Hospital — Abbotsford, British Columbia, Canada (Recruiting)
Study contacts
- Principal investigator: Fiona E Howarth — Fraser Health
- Study coordinator: Fiona E Howarth
- Email: fiona.howarth@fraserhealth.ca
- Phone: 6046143694
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.