Impact of Caffeine on the Blood Stem Cells in Healthy Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study administers a single 200 mg caffeine tablet to healthy adult participants under fasting conditions to examine its effects on blood hematopoietic cells. Participants are grouped by regular caffeine consumption versus minimal/no intake and blood samples are collected before and three hours after dosing. Outcomes include changes in mobilization of stem and progenitor cells from bone marrow into the bloodstream, as well as effects on cell function, gene activity, and metabolism. The trial uses a controlled, single-dose design with translational measurements in human subjects to understand caffeine’s immediate hematopoietic effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able to give consent.
* Healthy adults aged ≥ 18 years.
* Regular caffeine consumers (≥1 coffee cup/day or ≥1 energy drink/day) or non-consumers (≤1 cup/month and ≤1 energy drink/month) for at least 6 months.
* Willingness to comply with fasting requirements and study procedures.

Exclusion Criteria:

* Chronic illnesses or medication use affecting metabolism, including metabolic disorders (e.g., diabetes, thyroid dysfunction, metabolic syndrome).
* Personal history of cancer.
* Personal history of hematological disorders.
* History of radiation therapy.
* Known caffeine hypersensitivity or intolerance.
* Known immunosuppression.

Where it's running

• Eth Glc
  Zurich, Canton of Zurich, Switzerland Recruiting
• Eth Glc
  Zurich, Canton of Zurich, Switzerland Not yet recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Morning-strength boost with caffeine or whole-body vibration

  This study tests whether taking 300 mg caffeine or using whole-body vibration helps healthy, regularly trained adults see improvements in morning strength and thinking skills.

  Recruiting Phase 4 Liverpool John Moores University · Liverpool, Merseyside · NCT07921810

• How external factors affect 2D-NIRS tissue oxygenation measurements in healthy volunteers

  This study tests how things like temperature, activity, caffeine, and nicotine influence 2D-NIRS measurements of tissue oxygenation in healthy adults.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT07854431

• Does caffeine help professional chess players think faster and play better?

  In this study, professional chess players try caffeinated versus decaffeinated coffee to see if caffeine improves focus, reaction time, and game performance.

  Recruiting St. Louis University · St Louis, Missouri · NCT07641335

• Does Caffeine or Alcohol Change Pupil Reactions? A Test in Healthy Adults

  This study tests how caffeine and alcohol affect pupil responses and eye movements, and whether these changes can indicate recent intake, in adults aged 30-50.

  Recruiting National University of Singapore · Singapore · NCT07625358

• Sublingual caffeine to shorten recovery and reduce agitation after general anesthesia in older adults

  This trial will test whether a single dose of sublingual caffeine helps people aged 65 and older wake up faster and have less postoperative agitation after elective eye surgery under general anesthesia.

  Recruiting Cairo University · Cairo · NCT07536568

• Effects of caffeine on learning in healthy adults using brain imaging

  This study tests how caffeine affects learning and brain activity in healthy adults by comparing its effects to a placebo during tasks that involve rewards.

  Recruiting Phase 4 Martinos Center for Biomedical Imaging · Charlestown, Massachusetts · NCT06763172

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.