Impact of a Low-Sodium Salt Substitute on Potassium in Hypertension
Official title: The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension
Run by Johns Hopkins University · NCT07460882 · Data updated 2026-11-12
This study tests whether using a low-sodium salt substitute in adults with hypertension on medication can raise or lower potassium levels safely.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 607 (estimated) |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Dhaka) |
| Status | Recruiting |
| Started | August 8, 2026 |
| Main results expected | March 31, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | August 21, 2026 |
| Trial ID | NCT07460882 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with hypertension on stable antihypertensive medication and who have a phone for follow-up.
✕Probably not a fit
Patients with baseline potassium outside the eligible range, advanced kidney disease, or on potassium-sparing medications may not benefit and could be at risk.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pre-post study in Bangladesh investigates the effect of substituting a low-sodium salt product for regular salt among adults with hypertension on antihypertensive therapy. Participants will use the substitute for cooking and meals while reducing overall salt intake, with monitoring of potassium and related safety parameters. The study particularly focuses on those on renin-angiotensin system inhibitors and assesses the risk of hyperkalemia as well as potential correction of hypokalemia. Eligibility includes adults 18 and older on stable antihypertensive treatment, with exclusions for extreme potassium values, advanced kidney disease, certain diuretics, and specific health conditions. The Johns Hopkins University leads the effort with partnerships from the National Heart Foundation of Bangladesh and Vital Strategies at multiple sites in Dhaka.
Why it matters
Potential benefit: If successful, the approach could offer a practical way to manage potassium and blood pressure in hypertensive patients using salt substitutes.
How similar studies have gone: Previous work in related areas has shown mixed results; this study explores a context-specific, real-world approach in Bangladesh.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults ≥18 years with clinically diagnosed hypertension treated with medication \[on a stable dose at least for 2 months\] * Have a phone for contact Exclusion Criteria: * Those with baseline K ≥5.0 or K \<3.0 mmol/L * Advanced kidney disease (eGFR \<45 ml/min/1.73m2). * Those on potassium sparing diuretics (e.g., spironolactone) * Other medical conditions determined by physicians (e.g., heart failure treated with medication; life expectancy less than 12 months) * Dine out for dinner more than 3 times a week
Where it's running
-
The National Heart Foundation of Bangladesh
Dhaka, Bangladesh Recruiting
Study contacts
- Principal investigator: Junichi Ishigami, MD, PhD — Johns Hopkins University
- Study coordinator: Junichi Ishigami, MD, PhD
- Email: jishiga1@jhu.edu
- Phone: 14432877262
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.