Identifying patients at risk of heart attack during elective PCI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to validate the ABCD-GENE score, a precision medicine tool that integrates genetic and clinical data, to identify patients with stable coronary artery disease (CAD) who are at risk of experiencing myocardial infarction or myocardial injury during elective percutaneous coronary intervention (PCI). The study will involve a prospective cohort of 500 patients undergoing elective PCI while being treated with clopidogrel. By assessing platelet reactivity and troponin levels, the researchers hope to stratify patients based on their risk and potentially improve treatment outcomes. The findings could lead to better management strategies for patients undergoing PCI.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Stable CAD undergoing elective PCI;
2. Male or females, Age ≥ 18 years old;
3. Troponin negative before PCI\*;
4. Background of aspirin therapy;

   * If troponin is unknown before coronary angiography and no clinical signs of acute coronary syndrome is present, a troponin will not be collected as this is line with standard practice.

Exclusion criteria:

1. Current presentation with myocardial infarction;
2. On treatment with prasugrel or ticagrelor;
3. Documented hypersensitivity to clopidogrel;
4. Use of an intravenous antiplatelet therapy (i.e., cangrelor or GPI) during PCI;
5. Unable to provide written informed consent.

Where it's running

• University of Florida Jacksonville
  Jacksonville, Florida, United States Recruiting

Study contacts

• Principal investigator: Francesco Franchi, MD — University of Florida College of Medicine Jacksonville
• Study coordinator: Francesco Franchi, MD
• Email: francesco.franchi@jax.ufl.edu
• Phone: 9042442060

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.