Hyperbaric oxygen therapy for vocal performance in professional singers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, randomized, controlled trial investigates the effect of hyperbaric oxygen therapy on vocal performance in professional singers with vocal fold issues. Eligible participants are professional singers aged 18–70 who can attend regular visits and provide informed consent. The study will compare HBOT to a control condition to determine if HBOT enhances vocal function and health of the vocal folds. Traditional treatments often require downtime or have limited effectiveness, so HBOT could offer a novel option to support singers in maintaining performance readiness. Outcomes will focus on objective voice measures and perceived performance quality, with safety monitoring throughout the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 18-70
2. Professional singers for at least 3 months.
3. Subject willing and able to read, understand and sign an informed consent.

Exclusion Criteria:

1. Inability to attend scheduled clinic visits and/or comply with the study protocol
2. Substance use at baseline.
3. Any sever illness that based on the physician expected to deteriorate in the upcoming year.
4. HBOT for any reason prior to study enrolment
5. Chest pathology incompatible with pressure changes (including active asthma or COPD)
6. Ear or Sinus pathology incompatible with pressure changes (above 3 otolaryngologist visits a year)
7. An inability to perform an awake brain MRI
8. Active smoking
9. Participation in another study

Where it's running

• Assaf-Harofeh Medical Center
  Tsrifin, Israel Recruiting

Study contacts

• Study coordinator: Shai Efrati, Prof
• Email: efratishai@outlook.com
• Phone: +972-8-9779393

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.