Linking EEG signals with fMRI brain connectivity
Cross Modal Correlation of EEG and MRI Functional Connectivity: An Investigative Study
This study will test if brief dry‑electrode EEG recordings can reflect fMRI brain connectivity in adults who had a brain MRI at the Sagol Center.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assaf-Harofeh Medical Center Government |
| Locations | 1 site (Zrifin) |
| Trial ID | NCT07539506 on ClinicalTrials.gov |
What this trial studies
The study will collect dry‑electrode EEG from up to 1,500 adults who previously had a brain MRI at the Sagol Center and compare EEG connectivity patterns with their fMRI network maps. EEG data will be preprocessed for filtering, line‑noise and artifact removal, and down‑sampling, then analyzed by frequency band (alpha, beta, theta, delta), peak frequency, relative power, and power spectra. Functional connectivity and evoked responses will be computed across different EEG connectivity measures and brain atlas configurations, and correlations with fMRI connectivity will be examined, with AI methods used to aid pattern detection. The projected enrollment is about 1,500 participants over roughly 24 months at the Sagol Center / Shamir Medical Center in Zrifin.
Who should consider this trial
Good fit: Adults aged 18 or older who have already had a brain MRI at the Sagol Center, can cooperate with EEG testing, and can read and sign informed consent are ideal candidates.
Not a fit: People with scalp or skull abnormalities incompatible with EEG electrodes, known metal allergies, or who cannot cooperate with simple instructions are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the work could make inexpensive, bedside EEG a more useful proxy for fMRI functional mapping, improving access to brain network information.
How similar studies have performed: Previous research has shown partial correlations between EEG and fMRI connectivity with mixed results, and combining these modalities with AI is a relatively recent and promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or females aged 18 years or older. * Performed a brain MRI at the Sagol Center MRI Unit, at the Shamir Medical Center * Able to cooperate in an EEG evaluation * Can read and sign the informed consent. Exclusion Criteria: * Any scalp/bone abnormality incompatible with the EEG electrodes * Any known allergy to metals. * Inability to cooperate with simple instructions. * Inability to read and sign the informed consent.
Where this trial is running
Zrifin
- The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh) — Zrifin, Israel (Recruiting)
Study contacts
- Principal investigator: Shai Efrati, MD — Study Principal Investigator
- Study coordinator: Shai Efrati, MD
- Email: efratishai@outlook.com
- Phone: 972509212866
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.