Examining brain injury markers in patients after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between brain injury biomarkers found in cerebrospinal fluid and blood of patients who have experienced cardiac arrest. Following successful cardiopulmonary resuscitation, patients will undergo lumbar puncture at various time points to collect cerebrospinal fluid samples for analysis. The study aims to evaluate the prognostic value of these biomarkers in predicting patient outcomes after cardiac arrest. The collected samples will be analyzed using enzyme-linked immunosorbent assay (ELISA) to detect specific markers associated with brain injury.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years old.
* Still lack of directive movements after restoration of spontaneous circulation through cardiopulmonary resuscitation.
* Advanced life support and targeted temperature management are carried out within 6 hours after return of spontaneous circulation (ROSC).

Exclusion Criteria:

* Patients with contraindications for lumbar puncture (severe cerebral edema indicated by brain imaging, disappearance of basal cisterns or occult intracranial mass lesions, receiving antiplatelet and anticoagulant therapy, and those with coagulation disorders).
* Pregnant patients.
* Patients with concomitant traumatic brain injury, stroke, cerebral hemorrhage and other diseases.
* Patients whose families do not agree to be enrolled.

Where it's running

• Beijing chaoyang hospital
  Beijing, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.