Examining brain injury markers in patients after cardiac arrest
The Relationship Between Brain Injury Biomarkers in Cerebrospinal Fluid and Blood of Patients After Cardiac Arrest and Prognosis.
This study is trying to see if certain brain injury markers in the fluid around the brain and in the blood can help predict how well patients will recover after cardiac arrest.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Capital Medical University Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT06624488 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between brain injury biomarkers found in cerebrospinal fluid and blood of patients who have experienced cardiac arrest. Following successful cardiopulmonary resuscitation, patients will undergo lumbar puncture at various time points to collect cerebrospinal fluid samples for analysis. The study aims to evaluate the prognostic value of these biomarkers in predicting patient outcomes after cardiac arrest. The collected samples will be analyzed using enzyme-linked immunosorbent assay (ELISA) to detect specific markers associated with brain injury.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who exhibit a lack of directive movements after restoration of spontaneous circulation.
Not a fit: Patients with contraindications for lumbar puncture or those with concurrent severe brain injuries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve prognostic assessments and treatment strategies for patients recovering from cardiac arrest.
How similar studies have performed: While similar studies have explored biomarkers in brain injury, this specific approach focusing on cardiac arrest patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years old. * Still lack of directive movements after restoration of spontaneous circulation through cardiopulmonary resuscitation. * Advanced life support and targeted temperature management are carried out within 6 hours after return of spontaneous circulation (ROSC). Exclusion Criteria: * Patients with contraindications for lumbar puncture (severe cerebral edema indicated by brain imaging, disappearance of basal cisterns or occult intracranial mass lesions, receiving antiplatelet and anticoagulant therapy, and those with coagulation disorders). * Pregnant patients. * Patients with concomitant traumatic brain injury, stroke, cerebral hemorrhage and other diseases. * Patients whose families do not agree to be enrolled.
Where this trial is running
Beijing
- Beijing chaoyang hospital — Beijing, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.