How ventilator modes affect abdominal pressure and tube tolerance in ICU patients
Official title: Relationship Between Mechanical Ventilator's Modes , Intra-Abdominal Pressure, Mechanical Power and Gastric Tube Tolerance Among Mechanically Ventilated Patients.
Run by Damanhour University · NCT07687303 · Data updated 2026-11-12
This observational study tests how different mechanical ventilation modes influence intra-abdominal pressure and gastric tube tolerance in adults who need ventilation in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Damanhour University Academic / other |
| Locations | 1 site (Damanhūr) |
| Status | Recruiting |
| Started | August 2026 |
| Main results expected | October 2026 |
| Study ends | November 2026 |
| Registry record updated | July 7, 2026 |
| Trial ID | NCT07687303 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults in ICUs who require mechanical ventilation.
✕Probably not a fit
Patients with abdominal or chest trauma, intra-abdominal pathology, sepsis or organ dysfunction, BMI ≥ 30, or other exclusion criteria may not experience a benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study observes adult ICU patients on mechanical ventilation to see how ventilation modes relate to intra-abdominal pressure and gastric tube tolerance. It considers commonly used modes like SIMV, BIPAP, and CPAP and how they may affect respiratory and abdominal stresses. The findings could help identify ventilation practices that optimize breathing mechanics while reducing abdominal strain. The study does not assign interventions but rather analyzes real-world ventilation settings and patient responses.
Why it matters
Potential benefit: If successful, results could guide clinicians to choose ventilation modes that better balance breathing support with abdominal comfort and safety.
How similar studies have gone: Prior research has explored how ventilation settings influence chest pressures, but direct links to intra-abdominal pressure and gastric tube tolerance in this context are less established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients requiring MV in ICU Exclusion Criteria: * patients with abdominal or chest trauma, * patients with intra abdominal pathologies, * patients who had received more than 10 units of red blood cells or more than 5 liters of intravenous liquids over the last 24 h, * patients with sepsis or hepatic, or renal dysfunction, * patients in positions other than supine, and * body mass index (BMI) ≥ 30 kg/m2.
Where it's running
-
Faculty of Nursing, Damanhour University
Damanhūr, Egypt Recruiting
Study contacts
- Principal investigator: sahar youness youness, professor — professor of emergency and critical nursing
- Study coordinator: heba attia lecturer, lecturer
- Email: heba.attia@nur.dmu.edu.eg
- Phone: 045 01274855242
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.