Investigating mechanical power's role in respiratory failure and inflammation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the proportion of patients with acute hypoxemic respiratory failure (AHRF) who exceed a mechanical power threshold of 17 J/min during mechanical ventilation. It will compare proinflammatory cytokine concentrations in blood and bronchoalveolar lavage samples between patients with low and high mechanical power. The study will involve measuring respiratory mechanics and collecting biological samples to understand the relationship between mechanical power and inflammation in the lungs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with AHRF (P/F \<300 mmHg) undergoing invasive mechanical ventilation within 7 days from the onset of symptoms
* Invasive mechanical ventilation for less than 6 hours
* Evidence of newly developed lung consolidation on chest imaging (X-ray, CT)
* Age ≥18 years

Exclusion Criteria:

* Prior invasive mechanical ventilation during the same hospitalization
* Tracheostomy
* Severe anemia (Hb\<7g/dL)
* Severe neutropenia
* Renal insufficiency or RRT (Renal Replacement Therapy)
* Noradrenaline \>0.5 mcg/kg/min
* Pregnancy
* Extracorporeal circulation (ECCO2R, ECMO)
* Life expectancy \<24 hours as clinically judged
* Lack of consent

Where it's running

• Sapienza University of Rome
  Roma, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.