Evaluating the impact of transpulmonary mechanical power on patients with severe ARDS on ECMO

Effect of Transpulmonary Mechanical Power on the Prognosis of Patients With Severe Acute Respiratory Distress Syndrome Treated With Venovenous Extracorporeal Membrane Oxygenation

This study is trying to see if measuring the power of breathing machines can help doctors predict how well patients with severe lung problems on ECMO will do and improve their treatment.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Beijing Chao Yang Hospital (Academic / other)
• Locations: 1 site (Beijing, Beijing Municipality)
• Trial ID: NCT06062212 on ClinicalTrials.gov

What this trial studies

This observational study investigates the role of transpulmonary mechanical power in predicting the prognosis of patients suffering from severe acute respiratory distress syndrome (ARDS) who are receiving venovenous extracorporeal membrane oxygenation (VV-ECMO). The study aims to understand how mechanical ventilation settings can affect patient outcomes and the potential for ventilator-related lung injury. By focusing on transpulmonary pressure, the research seeks to provide insights into optimizing treatment strategies for ARDS patients on ECMO. The findings could help improve the management of these critically ill patients.

Who should consider this trial

Good fit: Ideal candidates for this study are patients diagnosed with severe ARDS who are currently receiving VV-ECMO support.

Not a fit: Patients who have been on high pressure ventilation for more than 7 days or have severe chronic lung disease with a life expectancy of less than 6 months may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved prognostic assessments and treatment strategies for patients with severe ARDS, potentially reducing mortality rates.

How similar studies have performed: While the specific approach of assessing transpulmonary mechanical power is novel, studies on mechanical ventilation and ECMO have shown varying degrees of success in improving patient outcomes.

Eligibility criteria

Inclusion Criteria:

1. Meet the diagnostic criteria of Berlin's definition for ARDS;
2. Receiving VV-ECMO support.

Exclusion Criteria:

1. Patients had been on high pressure (Ppeak \>35 cm H2O) and a high fraction of inspired oxygen (FiO2\>0.8) ventilation for \>7 days;
2. Patients had a contraindication to heparinization;
3. Patients had an irreversible neurological injury;
4. Patients had severe chronic lung disease with life expectancy \<6 months.

Where this trial is running

Beijing, Beijing Municipality

• Beijing Chao-Yang Hospital — Beijing, Beijing Municipality, China (Recruiting)

Study contacts

• Study coordinator: Yu Zhao, Dr.

Conditions Acute Respiratory Distress Syndrome; Extracorporeal Membrane Oxygenation; Mechanical Power; Transpulmonary Mechanical Power