Evaluating the impact of transpulmonary mechanical power on patients with severe ARDS on ECMO

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the role of transpulmonary mechanical power in predicting the prognosis of patients suffering from severe acute respiratory distress syndrome (ARDS) who are receiving venovenous extracorporeal membrane oxygenation (VV-ECMO). The study aims to understand how mechanical ventilation settings can affect patient outcomes and the potential for ventilator-related lung injury. By focusing on transpulmonary pressure, the research seeks to provide insights into optimizing treatment strategies for ARDS patients on ECMO. The findings could help improve the management of these critically ill patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Meet the diagnostic criteria of Berlin's definition for ARDS;
2. Receiving VV-ECMO support.

Exclusion Criteria:

1. Patients had been on high pressure (Ppeak \>35 cm H2O) and a high fraction of inspired oxygen (FiO2\>0.8) ventilation for \>7 days;
2. Patients had a contraindication to heparinization;
3. Patients had an irreversible neurological injury;
4. Patients had severe chronic lung disease with life expectancy \<6 months.

Where it's running

• Beijing Chao-Yang Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Yu Zhao, Dr.
• Email: xuanben1985@163.com
• Phone: +8618601342030

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Optimizing blood flow in patients on veno-venous ECMO

  This study is testing if adjusting blood flow during ECMO treatment can help patients with severe breathing problems get better oxygen without needing as much blood flow.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT04754854

• Full-Course ECMO Pathway for Moderate-to-Severe ARDS

  This study tests a standardized, full-course ECMO management pathway to see if it improves care for adults with moderate-to-severe ARDS treated with VV-ECMO in real-world Chinese centers.

  Recruiting at 15 sites Southeast University, China · Beijing and 38 other locations · NCT07726953

• How ventilator modes affect abdominal pressure and tube tolerance in ICU patients

  This observational study tests how different mechanical ventilation modes influence intra-abdominal pressure and gastric tube tolerance in adults who need ventilation in the ICU.

  Recruiting Damanhour University · Damanhūr · NCT07687303

• Height measurement methods to guide ventilator settings in ARDS

  We’re testing whether more precise height measurements change how researchers set lung-protective tidal volumes in adults with ARDS who are on a ventilator.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07595926

• Corticosteroids for a hyperinflammatory state in critical illness

  This trial tests whether methylprednisolone helps improve organ function and survival in adults with sepsis or ARDS who show a hyperinflammatory profile.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07511582

• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

  This project will follow adults with ARDS on mechanical ventilation to see how positive‑pressure breathing affects the right heart over time and how that relates to circulation.

  Recruiting Bicetre Hospital · Le Kremlin-Bicêtre · NCT07450846

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.