Lowering driving pressure during surgeries with high risk of postoperative lung complications
Official title: Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications
Run by University General Hospital of Patras · NCT07186933 · Data updated 2026-11-12
This trial tests whether using the lowest possible driving pressure during mechanical ventilation instead of standard protective settings helps adults having high-risk surgery avoid postoperative lung complications.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University General Hospital of Patras Academic / other |
| Locations | 1 site (Pátrai) |
| Status | Recruiting |
| Started | November 3, 2025 |
| Main results expected | August 31, 2027 |
| Study ends | November 30, 2027 |
| Registry record updated | February 11, 2026 |
| Trial ID | NCT07186933 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for surgery under general anesthesia who will be invasively ventilated and have a preoperative ARISCAT score above 25 are eligible candidates.
✕Probably not a fit
Patients who are pregnant, not having general anesthesia with endotracheal intubation, have severe heart failure or severe emphysematous lung disease, or cannot tolerate neuromuscular blockade or cessation of spontaneous ventilation are unlikely to participate or benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults at high risk for postoperative pulmonary complications (ARISCAT score >25) who undergo surgery with general anesthesia and invasive ventilation will receive one of two perioperative ventilation strategies. One group receives conventional lung-protective ventilation and the other undergoes PEEP titration to minimize driving pressure (ΔP). Investigators will compare rates of postoperative pulmonary complications as well as length of hospital stay, ICU admission, and mortality between the groups. All interventions and follow-up are performed at the University Hospital of Patras according to local perioperative care.
Why it matters
Potential benefit: If successful, the lower-driving-pressure approach could reduce postoperative lung complications, shorten hospital stays, and decrease ICU needs and possibly mortality for high-risk surgical patients.
How similar studies have gone: Observational studies and ARDS research associate lower driving pressure with better outcomes, but randomized evidence in high-risk surgical patients is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * \>17 years old * Surgery with general anesthesia \& invasive mechanical ventilation * Preoperative ARISCAT score estimation \>25 Exclusion Criteria: * \<18 years old * Preoperative ARISCAT score estimation \<26 * Women during pregnancy or just given birth * Other type of anesthesia (Not general) * Contraindication of administration of neuromuscular blockade agents. * Contraindication of cease of spontaneous ventilation. * Mechanical ventilation without endotracheal intubation. * Severe heart failure / Severe cardiac arrhythmia. * Severe emphysematous lung disease. * Patient denial of participation in the trial.
Where it's running
-
University Hospital of Patras
Pátrai, Greece Recruiting
Study contacts
- Principal investigator: Antonios Kostouros, Resident — University of Patras
- Study coordinator: Antonios D Kostouros, Resident
- Email: kostouros.a@yahoo.com
- Phone: +306975920528
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How the length of single-lung ventilation affects lung complications after chest surgery
This project sees if longer single-lung ventilation during thoracic surgery increases postoperative lung complications in adults aged 18–85.
-
Driving pressure-guided individualized PEEP vs standard PEEP during upper abdominal surgery
In this randomized trial, adults at higher risk of breathing problems after upper abdominal surgery will try a personalized PEEP level based on the lowest driving pressure and compare it to a fixed PEEP of 5 cmH2O to see if it lowers postoperative lung complications.
-
Early warning and stratified diagnosis of postoperative respiratory failure using ventilator waveform features
This study tests whether patterns in ventilator waveforms can predict and categorize risk of breathing failure after surgery for adults on mechanical ventilation.
-
How ventilator modes affect abdominal pressure and tube tolerance in ICU patients
This observational study tests how different mechanical ventilation modes influence intra-abdominal pressure and gastric tube tolerance in adults who need ventilation in the ICU.
-
See if reintubation risk can be predicted after major surgery
This observational study tests whether ultrasound measurements of the diaphragm and chest muscles, plus the ROX index, can help predict which adults in the ICU after major surgery might need reintubation.
-
Letting patients drink clear fluids until called to the operating room to shorten pre-surgery fasting
This project will try letting elective procedure patients drink clear liquids until they're called to the operating room to see if fasting times, comfort, and perioperative outcomes improve.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.