EIT versus dynamic compliance guidance for setting PEEP during laparoscopic gynecological surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized trial 200 adults undergoing elective laparoscopic gynecological surgery with otherwise non-injured lungs will be assigned to PEEP titration guided by either EIT or dynamic pulmonary compliance. The EIT group will receive decremental PEEP titration using a PulmoVista 500 device to identify an individual optimal PEEP, while the compliance group will use dynamic compliance–directed titration. Key outcomes include mechanical power of ventilation, oxygenation, respiratory mechanics, global inhomogeneity index, overdistension/collapse metrics and postoperative pulmonary complications. The study aims to determine whether EIT guidance can reduce ventilator mechanical power and related postoperative lung problems compared with the established compliance-guided approach.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Patient scheduled for elective laparoscopic gynaecological surgery
* Age \> 18 years
* Signed consent to participate in the trial

Exclusion criteria:

* Age \< 18 years
* American Society of Anesthesiologists (ASA) physical status IV
* History of severe restrictive or chronic obstructive pulmonary disease (COPD, Global Initiative for Chronic Obstructive Lung Disease grades III or IV)
* Uncontrolled bronchial asthma
* Pulmonary metastases
* History of any thoracic surgery
* Need for thoracic drainage before surgery
* Congestive heart failure (NYHA grades III or IV)
* Extreme obesity (BMI\>35 kg m-2)
* Lack of patient's consent

Where it's running

• Flór Ferenc Hospital Kistarcsa
  Kistarcsa, Pest County, Hungary Recruiting
• Semmelweis University
  Budapest, Budapest, Hungary Not yet recruiting
• Semmelweis Hospital Kiskunhalas
  Kiskunhalas, Bács-Kiskun county, Hungary Not yet recruiting

Study contacts

• Study coordinator: Zoltán Ruszkai, MD, PhD
• Email: ruszkai.zoltan@florhosp.hu
• Phone: 36-20-915-1978

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.