How long to fast after esophageal variceal ligation in cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized trial compares early postoperative oral intake with a 6-hour fast to delayed intake with 24- or 48-hour fasts in patients undergoing esophageal variceal ligation for portal hypertension. Participants are adults with cirrhosis and severe varices who have achieved hemostasis during EVL. The study aims to determine the impact on post-procedure rebleeding and safety outcomes. Patients are randomized to one of the fasting-duration arms and followed for postoperative events. The lead site is The First Affiliated Hospital of Zhengzhou University, with several collaborating centers in Henan Province.

Why it matters

Who can join: the full rules

Inclusion Criteria:

-1. The patient must be aged\>18 years; 2. The diagnosis of portal hypertension must be confirmed, with gastroscopy revealing severe esophageal varices and a positive red sign; 3. For patients undergoing endoscopic variceal ligation (EVL) due to esophageal varices (including those with hemorrhage or those eligible for elective ligation), successful intraoperative ligation is achieved (achieving hemostasis or completing the predetermined ligation procedure).

4\. Sign the informed consent form

Exclusion Criteria:

* 1\. Uncontrolled active bleeding or concurrent bleeding from gastric fundal varices; 2.History of prior TIPS, EVL, or surgical shunt procedures; 3. Presence of severe systemic diseases, such as sepsis, uremia, or advanced hepatocellular carcinoma (HCC); 4.Mechanical ventilation with retained catheter, inability to take oral intake, or significant dysphagia, or a history of major esophageal/gastric surgery that has impaired swallowing function; 5. Severe hepatic failure: Child-Pugh score\>13; profound jaundice (serum bilirubin\>10 mg/dL) accompanied by altered consciousness beyond Stage II or massive ascites; 6.Pregnancy or lactation; 7. Inability to provide informed consent.

Where it's running

• The Fifth People's Hospital of Anyang
  Anyang, China Recruiting
• The Secend People's Hospital of Jiaozuo
  Jiaozuo, China Recruiting
• Huaihe Hospital of Henan University
  Kaifeng, China Recruiting
• Luohe Central Hospital
  Luohe, China Recruiting
• Luoyang Central Hospital
  Luoyang, China Recruiting
• Nanyang Central Hospital
  Nanyang, China Recruiting

Study contacts

• Study coordinator: Hongxia Liang
• Email: hxliang@zzu.edu.cn
• Phone: 18595871806

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating carvedilol with or without endoscopic variceal ligation for preventing bleeding in cirrhotic patients

  This study is testing if adding a procedure called endoscopic variceal ligation to the medication carvedilol can better prevent bleeding in people with cirrhosis who aren't helped by carvedilol alone.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.