2D-shear wave spleen elastography to detect clinically significant portal hypertension and high-risk esophageal varices

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study that adds 2D-shear wave spleen elastography (SWE-SSM) to routine ultrasound examinations in eligible patients with compensated advanced chronic liver disease. Spleen and liver stiffness values (SWE-SSM and SWE-LSM, and transient elastography when available) will be recorded without altering standard care and compared to clinical markers of portal hypertension. A subgroup of patients undergoing hepatic venous pressure gradient (HVPG) measurement will allow direct correlation between spleen stiffness and portal pressure. Participants are enrolled at Policlinico A. Gemelli in Rome and must meet predefined liver stiffness cutoffs while excluding conditions such as TIPS, splenectomy, grade 3 ascites, or prior variceal bleeding.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age greater than 18 years;
* SWE-LSM ≥9 kPa and/or TE-LSM ≥15 kPa;

Exclusion Criteria:

* Presence of transjugular intrahepatic porto-systemic shunt (TIPS);·
* Surgical absence of the spleen;
* Grade 3 ascites;
* History of variceal bleeding;
* Refusal to participate in the study.

Where it's running

• Ultrasound diagnostic and interventional service "Policlinico A.Gemelli"
  Roma, Italia, Italy Recruiting

Study contacts

• Study coordinator: Matteo Garcovich doctor
• Email: matteo.garcovich@policlinicogemelli.it
• Phone: 0039 0630156018

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Endovascular treatment outcomes after portal hypertension–related GI bleeding in cirrhosis

  This study tests how well endovascular procedures for portal hypertension–related GI bleeding work in adults with cirrhosis, and what factors predict outcomes.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City · NCT07918378

• How long to fast after esophageal variceal ligation in cirrhosis

  This trial tests whether starting oral intake 6 hours after EVL is safer and as effective as waiting 24 or 48 hours in adults with cirrhosis and esophageal varices.

  Recruiting at 12 sites The First Affiliated Hospital of Zhengzhou University · Anyang and 11 other locations · NCT07774143

• Factors that affect reopening of blocked portal veins in people with cirrhosis and gastroesophageal varices

  This project looks at past records and follow-up to see which factors are linked with reopening (recanalization) of blocked portal veins in people who have cirrhosis and endoscopy-confirmed gastroesophageal varices.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07473375

• VIATORR TIPS 6–10 mm: Real-world use in cirrhosis with portal hypertension

  A real-world registry is seeing how the GORE VIATORR TIPS Endoprosthesis with Controlled Expansion 6-10 mm works over 2 years in adults with cirrhosis and portal hypertension.

  Recruiting at 5 sites W.L.Gore & Associates · Atlanta, Georgia and 4 other locations · NCT07390344

• MRI versus ultrasound for early liver cancer detection, body composition, and decompensation risk in cirrhosis

  This project will test whether abbreviated MRI or ultrasound is better at finding early liver cancer and measuring muscle and fat in adults with cirrhosis.

  Recruiting Linkoeping University · Linköping, Select A State Or Province · NCT07291141

• TIPS procedure with or without oral branched-chain amino acids (BCAA)

  This test will try giving oral BCAA supplements for three months after TIPS in adults with cirrhosis and sarcopenia to see if it improves muscle and clinical outcomes.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT07281846

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.