How Different Levels of CPAP Deliver Oxygen to Preterm Babies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study aims to measure the true oxygen delivery to preterm infants on nasal CPAP and how it may vary with different airway pressures. Researchers will collect measurements that are difficult to obtain in typical clinical care to see if the doctor-ordered oxygen matches what reaches the baby’s airway. The study focuses on infants born before 35 weeks who are stable on CPAP and using 22-40% supplemental oxygen, excluding those with higher oxygen needs or invasive ventilation. Findings could clarify whether adjustments in CPAP pressure change actual oxygen delivery and lung expansion. The study is conducted at the University of Arkansas for Medical Sciences in Little Rock, led by that institution.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Gestational age at birth must be less than 35 weeks of completed gestation as documented in the subject's initial history and physical
* The infant must be stable while receiving nasal CPAP at any pressure level at the time of study
* The infant must be receiving 22-40% at the time of the study

Exclusion Criteria:

* Oxygen requirements greater than 40% at time of enrollment
* currently receiving invasive ventilation or not requiring ventilatory support
* Major congenital anomalies of the heart and/or lungs

Where it's running

• University of Arkansas for Medical Sciences
  Little Rock, Arkansas, United States Recruiting
• University of Arkansas for Medical Sciences
  Little Rock, Arkansas, United States Not yet recruiting

Study contacts

• Study coordinator: Nicholas A Rowley, MD
• Email: NARowley@uams.edu
• Phone: 940-230-5002

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.