Lung volume changes with synchronized noninvasive ventilator support in preterm infants
Official title: Intrapulmonary Volume Changes During Synchronized Noninvasive Positive Pressure Ventilation In Preterm Infants
Run by University of Zurich · NCT07237139 · Data updated 2026-11-12
This study will use a noninvasive imaging belt to see if synchronized ventilator inflations produce larger lung volumes than unsynchronized or backup inflations in very preterm infants on sNIPPV.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 4 Weeks |
| Sex | All |
| Enrollment | 27 (estimated) |
| Sponsor | University of Zurich Academic / other |
| Locations | 1 site (Zurich, Canton of Zurich) |
| Status | Recruiting |
| Started | November 17, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | January 30, 2027 |
| Registry record updated | December 9, 2025 |
| Trial ID | NCT07237139 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are infants born before 30 0/7 weeks gestation, under 4 weeks old, receiving synchronized NIPPV and whose parents provide written informed consent.
✕Probably not a fit
Infants with severe congenital malformations affecting lung aeration or perfusion, those judged too unstable by the treating physician, older than 4 weeks, or not receiving sNIPPV are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study records lung impedance with Electrical Impedance Tomography (EIT) in preterm infants receiving synchronized noninvasive positive pressure ventilation (sNIPPV). An EIT belt and pulse oximeter are applied and recordings include a 2-minute CPAP baseline followed by return to sNIPPV while the ventilator and abdominal capsule (Graseby) provide synchronization. The primary endpoint is the difference in relative tidal volume (rel. Delta-Z) between spontaneous breaths and synchronized inflations; secondary analyses examine regional aeration and ventilation differences. The ventilator used is the EVEneo and the protocol compares spontaneous, synchronized, non-synchronized, and backup inflations to characterize intrapulmonary mechanisms.
Why it matters
Potential benefit: If successful, the results could help clinicians fine-tune ventilator timing to improve lung aeration and possibly reduce respiratory failure in very preterm infants.
How similar studies have gone: Clinical trials have shown synchronized NIPPV reduces respiratory failure compared with non‑synchronized modes, but using EIT to detail the intrapulmonary volume changes during different inflation types is a relatively novel, more mechanistic application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Written informed consent by one or both parents or legal guardians * Gestational age at birth \< 30 0/7 weeks * Infants on sNIPPV respiratory support * Below 4 weeks chronological age Exclusion Criteria: * Severe congenital malformation adversely affecting lung aeration or perfusion (e.g., congenital heart defects) * Too ill/unstable in the opinion of the treating physician.
Where it's running
-
University Hospital Zurich
Zurich, Canton of Zurich, Switzerland Recruiting
Study contacts
- Study coordinator: Christoph M Rüegger, MD
- Email: christoph.rueegger@usz.ch
- Phone: +41432539810
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.