How different irrigation activation methods affect retreatment of failed root canals
Official title: Evaluation of the Effect of Different Irrigation Activation Methods During Endodontic Retreatment on Postoperative Pain and Periapical Healing in Single-Rooted Teeth: A Randomized Controlled Clinical Trial
Run by Minia University · NCT07779148 · Data updated 2026-11-12
This study tests whether using ultrasonic activation or XP Endo Finisher R during retreatment helps clean the canals better in adults with a previously failed root canal and periapical disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 13 Years to 60 Years |
| Sex | All |
| Enrollment | 34 (estimated) |
| Sponsor | Minia University Academic / other |
| Locations | 1 site (Minya) |
| Status | Recruiting |
| Started | August 1, 2026 |
| Main results expected | August 1, 2027 |
| Study ends | August 10, 2027 |
| Registry record updated | August 21, 2026 |
| Trial ID | NCT07779148 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with mature, single-rooted teeth that have failed prior endodontic treatment and have periapical periodontitis, willing to consent and complete follow-up.
✕Probably not a fit
Patients with immature roots, systemic diseases affecting healing, swelling, pregnancy, or inability to participate in follow-up may not benefit from the intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study evaluates endodontic retreatment techniques in mature, single-rooted teeth with persistent periapical disease after prior treatment. The focus is on activating irrigation to improve cleaning of the canal and disinfection, potentially reducing residual debris and bacterial load. Ultrasonic activation and the XP Endo Finisher R are explored as methods to enhance removal of filling materials and improve outcomes. Participants will undergo retreatment and be followed to assess healing and post-procedural effects. The trial aims to determine if these activation methods offer meaningful advantages over conventional irrigation during retreatment.
Why it matters
Potential benefit: If successful, patients may experience better cleaning of the root canal system, leading to improved healing and long-term success after retreatment.
How similar studies have gone: Previous research suggests activation methods can improve canal cleaning and disinfection during retreatment, though results vary by technique and anatomy.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with mature teeth. * Patients with failed previous Endo treatment related by periapical periodontitis * Single Rooted with single root canal. * Patients should be free from any systemic disease that may affect predictable outcome. * Patients who agree to the consent and will commit to follow-up period Exclusion Criteria: * Patients with immature roots. * Patients with any systemic disease that may affect normal healing. * Patients with swelling. * Pregnant females. * Patients who could/would not participate in follow-up. * Patients with old age. * Teeth with periodontal involvement. * Teeth with vertical root fractures. * Non-restorable teeth
Where it's running
-
Dentistery Hospital, Minia University
Minya, Egypt Recruiting
Study contacts
- Study coordinator: Magdy Mohy Eldeen Abdulrazzak, MSC
- Email: Dentist.magdy@gmail.com
- Phone: +201153661666
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.