Home oxygen with high-flow therapy vs standard oxygen for chronic lung and heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial compares two home oxygen strategies in adults with chronic respiratory or cardiac disease who require long-term oxygen. Participants will alternate two-week periods of HFNC therapy using the myAirvo3 device and standard oxygen therapy, with a short break between periods, to directly compare effects within the same person. Remote monitoring will track oxygen levels, heart rate, symptoms, and sleep to help researchers understand tolerability and potential benefits. A wearable device will monitor night-time breathing pauses and heart rhythm. The study aims to determine whether HFNC provides better comfort and daily functioning than standard oxygen in a home setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥18 years) with chronic respiratory (e.g., COPD, interstitial lung disease) and/or cardiac disease (e.g., heart failure),
* Clinical indication for long-term oxygen therapy,
* Capability to manage home-based devices independently or with caregiver assistance
* Signed informed consent

Exclusion Criteria:

* Life expectancy \< 3 months
* Inability to comply with home follow-up procedures.

Where it's running

• Savino SPADARO
  Ferrara, Italy, Italy Recruiting

Study contacts

• Study coordinator: Savino Spadaro, Associate professor
• Email: spdsvn@unife.it
• Phone: +393894841243

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Weaning HFNC: When to Stop High-Flow Oxygen in Acute Respiratory Failure

  This study tests a protocol to guide when to stop high-flow nasal therapy in adults with acute respiratory failure who are already on HFNC.

  Recruiting University of Milan · Milan, Lombardy and 1 other locations · NCT07638293

• Turkish version of the S3-NIV questionnaire: testing its reliability for home NIV patients

  We’re testing whether the Turkish S3-NIV questionnaire reliably measures how well patients on home non-invasive ventilation can manage daily use and comfort.

  Recruiting Istanbul Saglik Bilimleri University · Istanbul · NCT07610122

• Extra oxygen during the 6-minute walk for people with chronic respiratory failure or exercise-related low oxygen

  This trial will test whether giving extra oxygen during a 6-minute walk helps people with chronic respiratory failure or exertional low oxygen from COPD or interstitial lung disease walk farther, breathe better, and feel easier during the test.

  Recruiting at 4 sites Istituti Clinici Scientifici Maugeri SpA · Lumezzane, Brescia and 5 other locations · NCT07451977

• Machine learning to detect inspiratory leak in long-term non-invasive ventilation

  This project tries to use a machine-learning program to detect inspiratory leaks in people with chronic respiratory failure who use long-term non-invasive ventilation.

  Recruiting University of Oslo · Oslo · NCT07428694

• Monitoring breathing muscle function in ARF patients on non-invasive support

  This study tests whether advanced breathing-muscle monitoring can help care teams manage adults with acute respiratory failure who are on non-invasive respiratory support.

  Recruiting at 2 sites Queen Mary University of London · London and 1 other locations · NCT07423338

• Comparing 3D/2D electrical impedance tomography and the R/I ratio to measure lung recruitability during mechanical ventilation

  This test tries to see if two imaging methods (3D and 2D electrical impedance tomography) and a pressure-based recruitment-to-inflation (R/I) ratio give consistent estimates of how much the lungs can be recruited in sedated adults on mechanical ventilation for acute respiratory failure.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07379242

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.