Comparing 3D/2D electrical impedance tomography and the R/I ratio to measure lung recruitability during mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational protocol that compares lung recruitability estimates from 3D-EIT, 2D-EIT, and the recruitment-to-inflation (R/I) ratio in mechanically ventilated adults with acute respiratory failure. Participants undergo a standardized PEEP titration while synchronized EIT monitoring records regional impedance changes and R/I ratios are measured at high and low PEEP levels. The study examines agreement and differences between the techniques rather than testing a therapeutic intervention. Patients with contraindications to EIT, hemodynamic intolerance to high PEEP, or other predefined exclusions are not enrolled.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.
* Oxygenation index \< 300 mmHg.
* Patients who are clinically judged by the attending doctor to require the PEEP titration.

Exclusion Criteria:

* Aged under 18 years.
* Pregnancy.
* Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).
* No informed consent obtained.
* Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.
* High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.

Where it's running

• Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Huaiwu He
• Email: tjmuhhw@126.com
• Phone: 010-6915-2300

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.