Monitoring breathing muscle function in ARF patients on non-invasive support

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients with acute respiratory failure on non-invasive support may still deteriorate; this trial uses advanced monitoring methods to observe how the diaphragm and chest muscles perform during non-invasive ventilation. The study focuses on real-time assessment to identify fatigue or inadequate support, aiming to guide management decisions. It is an interventional study led by Queen Mary University of London at Royal London Hospital and Newham Hospital. Participants include adults on non-invasive support and require multidisciplinary care involvement; those needing immediate intubation or with certain severe conditions are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult (≥18 years old)
* with acute respiratory failure with hypoxia (i.e. arterial oxygen tension (PaO2) of \<8.0 kPa), and/or with or without hypercapnia (i.e. arterial carbon dioxide tension (PaCO2) of \>6.0 kPa) from any underlying disease or cause
* requiring any non-invasive respiratory support (i.e. HFNO, CPAP, BiPAP)
* Multidisciplinary critical care staff involved in the management of those recruited patients with acute respiratory failure requiring non-invasive respiratory supports. Staff will possibly have an interview and are also required to complete a questionnaire.

Exclusion Criteria:

* Patients in respiratory arrest defined as the total cessation of airflow and breathing effort and absent ventilation (24,25)
* Patients requiring immediate intubation
* Patients with Glasgow Coma Scale (GCS) \< 8
* Patients with severe facial trauma or burns
* Patients with fixed upper airway obstruction or inability to protect the airway
* Patients with severe agitation and/or confusion that prevent use of the device mask
* Patients with severe vomiting
* Pregnancy
* Patients with pacemakers and other electronic devices in the thorax
* Patients on end-of-life care or palliative care (defined as expected to die and/or not receiving active treatment)
* Contra-indication to EIT or ultrasound monitoring (e.g. burns, severe obesity, thoracic wounds limiting instrument placement, and thoracic drain)

Where it's running

• Royal London Hospital
  London, United Kingdom Recruiting
• Newham Hospital
  London, United Kingdom Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.