Home-based brain stimulation with virtual speech therapy for logopenic PPA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with logopenic variant PPA who meet cognitive and technical criteria are randomized to receive either active remotely supervised tDCS plus virtual lexical retrieval therapy or sham tDCS plus the same virtual therapy. Treatments are delivered at home with remote supervision and outcome measures include communication tests, feasibility and acceptability metrics, and MRI-based brain measures collected at the research site. The trial will compare changes in language and communication between the active and sham groups and explore whether individual brain characteristics predict response. Study partners co-enroll to attend on-site training and support remote treatment sessions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meets diagnostic criteria for primary progressive aphasia (PPA)
* Meets diagnostic criteria for logopenic variant PPA
* Attains score of 15 or higher on the Mini-Mental State Examination
* Has adequate hearing and vision (with hearing or vision aids, if needed)
* Is able to travel to research site and undergo MRI brain scan
* Has access to high speed internet and basic experience using a computer and the internet
* Is a fluent speaker of English
* Has a study partner who can co-enroll in the study, attend pre-treatment training at the research site, and be present for teleconference meetings, as needed

Exclusion Criteria:

* Speech and language deficits better accounted for by another neurological disorder
* Does not meet diagnostic criteria for logopenic variant PPA
* Scores less than 15 on the Mini-Mental State Examination
* Does not have a study partner who can co-enroll in the study
* Has contraindications for tDCS or MRI scan (History of seizures, head injury, craniotomy, skull surgery or fracture; History of severe or frequent migraines; Metallic implant in head or any metal in head; Pacemaker or cardioverter-defibrillator or any other stimulator; Chronic skin problems; Pregnancy)
* Has a history of stroke, epilepsy, or significant brain injury

Where it's running

• UCSF Memory and Aging Cener
  San Francisco, California, United States Recruiting
• University of Texas
  Austin, Texas, United States Recruiting

Study contacts

• Principal investigator: Maya L Henry, PhD — University of Texas at Austin
• Study coordinator: Aphasia Lab Research Coordinator
• Email: aphasialab@austin.utexas.edu
• Phone: 512-471-3420

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.