Speech and language therapy for Italian patients with primary progressive aphasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of speech and language interventions for Italian patients diagnosed with primary progressive aphasia (PPA). A total of 30 patients will undergo a series of assessments, including clinical interviews, neurological evaluations, and speech assessments, both before and after the intervention. The study will also include brain MRI scans to analyze structural and functional changes. The goal is to measure improvements in communication abilities and patient satisfaction over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of PPA according to the current clinical criteria (Gorno-Tempini et al., 2011)
* Mild PPA defined using the Progressive Aphasia Severity Scale (PASS)
* Age between 40 and 85 years
* Patients with Italian mother tongue
* Patients with the ability to sign the informed consent
* Patients with the ability to comply with the study procedures
* Patients with stable pharmacological treatment for at least 4 weeks.

Exclusion Criteria:

* Mini-Mental State Exam (MMSE) Score \<15
* Presence of other neurological or psychiatric diseases, including cerebrovascular disease
* Severe and uncorrected hearing loss or visual disturbances
* Inability to repeat multi-syllable words (4 syllables)
* Concurrent participation in other pharmacological and non-pharmacological experimental studies

Where it's running

• Istituti Clinici Scientifici Maugeri IRCCS
  Bari, Italy Recruiting
• IRCCS Ospedale San Raffaele
  Milan, Italy Recruiting

Study contacts

• Study coordinator: Petronilla Battista, PhD
• Email: petronilla.battista@gbhi.org
• Phone: +390807814331

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Home-based brain stimulation with virtual speech therapy for logopenic PPA

  This project will test whether home-based transcranial direct current stimulation (tDCS) combined with virtual speech-language therapy helps people with the logopenic variant of primary progressive aphasia communicate better.

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• Personalized virtual speech therapy to improve communication in primary progressive aphasia

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  Recruiting University of Texas at Austin · Austin, Texas · NCT07219680

• Long-term brain stimulation for primary progressive aphasia

  This trial will test whether two non-invasive brain stimulation methods (TMS and tDCS), alone or combined and paired with language therapy, can slow or improve language decline over six months in people with primary progressive aphasia.

  Recruiting Hospital San Carlos, Madrid · Madrid · NCT07158216

• Creating a repository for neurodegenerative disease data

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  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT04715399

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.