Higher or lower starting FSH dose for good-prognosis IVF with PPOS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized study, women with good IVF prognosis undergoing progestin-primed ovarian stimulation will be assigned to start with either 225 IU or 300 IU of FSH. The primary outcome is the blastocyst formation rate, with secondary outcomes including oocyte quality, fertilization, embryo development, and blastocyst quality. Participants are followed through their first frozen embryo transfer cycle to assess additional outcomes. The study is conducted at An Sinh Hospital in Ho Chi Minh City under the sponsorship of Vietnam Military Medical University.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female patient or oocyte donor aged \<35 years.
* Body mass index (BMI) between 18 and 25 kg/m².
* Normal ovarian reserve, defined by:

  * Antral follicle count (AFC) ≥8 on ultrasound; and
  * AMH level between 1.5 and 4.5 ng/mL.
* First IVF treatment cycle.
* Controlled ovarian stimulation using a progestin-primed ovarian stimulation (PPOS) protocol with recombinant FSH and dydrogesterone.
* Indication for in vitro fertilization using intracytoplasmic sperm injection (ICSI).
* Indication for extended embryo culture to the blastocyst stage.
* Willingness to participate in the study and provision of written informed consent.

Exclusion Criteria:

* Polycystic ovary syndrome (PCOS) diagnosed according to the Rotterdam criteria, currently referred to as polyendocrine metabolic ovarian syndrome (PMOS).
* Structural abnormalities of the ovaries.
* Ovarian endometriosis.
* Medical or gynecological conditions that may affect ovarian response to controlled ovarian stimulation.
* Indication for luteinizing hormone (LH) supplementation during controlled ovarian stimulation.
* Poor sperm quality, cryptozoospermia, surgically retrieved sperm (PESA, TESE, or microTESE), cryopreserved sperm, or donor sperm.
* Indication for artificial oocyte activation (AOA) or rescue ICSI (R-ICSI).

Where it's running

• An Sinh Hospital
  Ho Chi Minh City, Ho Chi Minh City, Vietnam Recruiting

Study contacts

• Principal investigator: Truc Nhu Thanh Vo, PhD Student — Vietnam Military Medical University
• Study coordinator: Truc Nhu Thanh Vo, PhD Student
• Email: vonhuthanhtruc.art@gmail.com
• Phone: +84 0764681310

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.