Integrative care guided by biological aging markers for unexplained female infertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Women aged 25–42 with persistent post‑treatment unexplained infertility undergo baseline reproductive evaluation and telomere and other biological aging biomarker profiling. Based on these profiles, participants receive a personalized integrative intervention that includes botanical and nutraceutical therapies prior to attempts at natural conception or continuation of assisted reproductive technologies (ART). The trial tracks clinical pregnancy and related reproductive outcomes to compare the biomarker-guided integrative approach with usual care pathways. The protocol also aims to define a biological aging phenotype associated with reproductive failure and determine whether targeting cellular aging processes improves outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Biological female participants aged 25 to 42 years.
* Diagnosis of infertility defined as failure to conceive after at least 12 months of unprotected intercourse and/or repeated failure of assisted reproductive technologies (ART), including intrauterine insemination (IUI) and/or in vitro fertilization (IVF).
* History of post-treatment unexplained or functionally idiopathic infertility, defined as persistent infertility despite adequate correction or management of identifiable reproductive conditions (e.g., endometriosis, polycystic ovary syndrome, hormonal imbalance, uterine factors).
* Eligibility for natural conception attempts and/or assisted reproductive technologies according to routine clinical practice.
* Willingness to undergo biological aging biomarker profiling, including leukocyte telomere analysis.
* Ability and willingness to comply with study procedures, including the preconception integrative intervention and follow-up assessments.
* Provision of written informed consent prior to participation.

Exclusion Criteria:

* Current pregnancy or breastfeeding at the time of enrollment.
* Known chromosomal abnormalities or genetic conditions directly impairing fertility (e.g., Turner syndrome).
* Untreated severe male factor infertility precluding conception by natural or standard ART methods.
* Active malignancy or history of cancer requiring systemic treatment within the past 5 years.
* Severe systemic disease or medical condition contraindicating pregnancy or participation in ART (as determined by the treating physician).
* Use of investigational drugs or participation in another interventional clinical trial that could interfere with the study outcomes.
* Known hypersensitivity or contraindication to components of the integrative intervention, as determined by clinical assessment.
* Any condition which, in the opinion of the investigator, would interfere with safe participation or interpretation of study results.

Where it's running

• BEYOND GENOMiX Research and Coordination Center
  Neuchâtel, Switzerland Recruiting

Study contacts

• Study coordinator: M. Merarchi
• Email: pm@beyondgenomix.com
• Phone: +4132 552 60 00

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Higher or lower starting FSH dose for good-prognosis IVF with PPOS

  This trial tests whether starting IVF stimulation with 225 IU or 300 IU of FSH improves oocyte and embryo outcomes in good-prognosis women using PPOS.

  Recruiting Vietnam Military Medical University · Ho Chi Minh City, Ho Chi Minh City · NCT07772375

• Environmental and lifestyle factors linked to ART success in infertility patients

  This study follows 5,000 infertile men and women to see how environmental exposures and lifestyle relate to the success of assisted reproductive technology.

  Recruiting The Third Xiangya Hospital of Central South University · Changsha, Hunan · NCT07641387

• Measuring Uterine Elasticity in Women During Their Menstrual Cycle

  This study is testing how stretchy the uterus and ovaries are at different times during the menstrual cycle to see if this information can help women with fertility treatments.

  Recruiting Reproductive Medicine Associates of New Jersey · Basking Ridge, New Jersey · NCT06816381

• Exploring how language affects fertility treatment progress

  This study is testing whether Spanish-speaking patients have a better experience and faster progress in fertility treatments when they communicate with a Spanish-speaking provider instead of using an interpreter.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06636838

• Using artificial intelligence to improve oocyte and embryo quality assessment in fertility treatments

  This study is testing whether using artificial intelligence can help improve the quality of eggs and embryos in fertility treatments like IVF to boost the chances of pregnancy.

  Recruiting at 4 sites Charles University, Czech Republic · Prague and 3 other locations · NCT06539104

• Differential Granulosa Cell Transcriptome Profiling to Predict Ongoing Pregnancy

  Aiming to see if differences in granulosa cell gene activity can predict ongoing pregnancy in IVF and oocyte donation with PGT-A.

  Recruiting Vida Recoletas Sevilla · Seville, Sevilla · NCT07929779

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.