German registry for dementia and early memory problems

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The German Dementia Registry is a prospective, multicenter platform that collects longitudinal real-world clinical data and biomarker results from patients with SCD, MCI, and early dementia across participating German sites. Data are entered via an online platform and aligned with diagnostic and treatment guidelines to capture routine clinical practice. The registry will track disease progression, biomarker dynamics (for example CSF amyloid and tau measures), and treatment patterns to help distinguish Alzheimer's disease from other dementia causes. Collected information is intended to support improved early diagnostic criteria and inform use of newly approved treatments in real-world settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Inclusion Criteria for Patient:

* Ability of the participant and/or his/her legally authorized representative (e.g., spouse or legal guardian), as appropriate and applicable, to understand the purpose and risks of the register and provide signed and dated informed consent and authorization to use protected health information (PHI) in accordance with national and local privacy regulations.
* Participating patients must have a diagnosis of SCD, MCI or early dementia of different etiology (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy-Body Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Normal Pressure Hydrocephalus, Major Depression; Vascular Dementia; TDP-43 associated limbic encephalopathy (LATE), Mixed Dementia AD + VaD, Prion-Associated Dementia) together with biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42/amyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.
* At least 18 years of age.

Inclusion Criteria for family member:

* At least 18 years of age.
* Patient was included in the registry
* Family member is strongly involved to the patient's life according to the patient's statement
* Ability of the participant, as appropriate and applicable, to understand the purpose and risks of the register

Exclusion Criteria:

Exclusion Criteria for Patient:

* Unwilling to provide informed consent.
* No available biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42/amyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.

Exclusion Criteria for family member:

* Unable or unwilling to provide informed consent.

Where it's running

• Heidelberg University Hospital
  Heidelberg, Baden-Wurttemberg, Germany Recruiting
• ZI Mannheim
  Mannheim, Baden-Wurttemberg, Germany Recruiting
• University Hospital Tübingen
  Tübingen, Baden-Wurttemberg, Germany Recruiting
• Ulm University Hospital
  Ulm, Baden-Wurttemberg, Germany Recruiting
• Universitätsklinikum Erlangen
  Erlangen, Bavaria, Germany Recruiting
• Klinikum Frankfurt (Oder)
  Frankfurt (Oder), Brandenburg, Germany Recruiting

Study contacts

• Principal investigator: Jörg B. Schulz, Prof. Dr. — Department of Neurology, RWTH Aachen University Hospital
• Study coordinator: Prof. Dr. Jörg B. Schulz, MD
• Email: NE-Wissenschaftsmanagement@ukaachen.de
• Phone: +49 241 80-89600

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.