Clinical trial Recruiting at 1 site Interventional Ages 18 to 40

Fasting for 84 Hours: How It Affects Fat Burning and Muscle Basics in Young Adults

Official title: The Effect of Fasting on Peak Fat Oxidation, Mitochondrial Coupling and Extracellular Matrix in Healthy Men and Lean and Obese Men and Women

Run by University of Copenhagen · NCT07692646 · Data updated 2026-11-12

This study tests whether 84 hours of fasting changes peak fat oxidation, how efficiently mitochondria couple their energy, and the extracellular matrix in four groups of young people who are normal weight or obese.

More Fasting trials

Quick facts

Study typeInterventional
Ages18 Years to 40 Years
SexAll
Enrollment40 (estimated)
SponsorUniversity of Copenhagen
Academic / other
Locations1 site (Copenhagen)
StatusRecruiting
StartedJune 2026
Main results expectedAugust 2027
Study endsDecember 2033
Registry record updatedJuly 9, 2026
Trial IDNCT07692646 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are healthy men and women aged 18-40 with BMI 18-25 or 30-40 who can comply with dietary records and fasting procedures.

Probably not a fit

Participants who do not experience changes in fat metabolism or who have adverse reactions to fasting may not see direct benefits.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Four groups of young adults (10 per group) will fast for 84 hours and have measurements taken before and after. The study uses DXA for body composition, indirect calorimetry for resting energy expenditure, blood tests, and tissue biopsies from muscle and abdominal fat. Participants follow a measured dietary and activity plan before testing and consent is obtained after information is provided. The goal is to see if fasting alters fat metabolism and tissue properties differently by weight status and sex.

Why it matters

Potential benefit: If successful, the findings could improve understanding of how prolonged fasting affects fat use and muscle biology in young adults with varying BMI.

How similar studies have gone: Prior research has explored fasting effects on metabolism, but this study is unique in combining fat oxidation, mitochondrial coupling, and extracellular matrix analysis across weight groups.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Healthy normal weight men aged \[18,40\] and BMI \[18,25\]
* Healthy normal weight women \[18,40\] and BMI \[18,25\]
* Healthy obese men \[18,40\] and BMI \[30,40\]
* Healthy obese women \[18,40\] and BMI \[30,40\]

Exclusion Criteria:

* Present or former cardiovascular disease and chronical inflammatory disease
* Consumption of medications and supplements that influence substrate use at rest and/or during exercise
* Pregnancy

Where it's running

  • Department of Biomedical Sciences
    Copenhagen, Denmark
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.