Finding who is at high risk for inflammatory bowel disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will follow people at higher risk for IBD—including first-degree relatives, patients with certain autoimmune diseases, and ASCA-positive functional GI patients—and compare them with healthy and IBD populations. Participants will provide demographic and clinical information, complete symptom questionnaires at regular intervals, and give blood and stool samples for genomic, proteomic, metabolomic, and microbiome (16S and whole genome shotgun) analyses. When clinical colonoscopy occurs, biopsy tissue will be collected for proteomic study, and adverse events related to blood sampling will be monitored in the outpatient clinic. The goal is to identify patterns of risk factors that precede IBD onset.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* first-degree relatives of Inflammatory Bowel Disease patients
* patients who are diagnosed with autoimmune diseases
* patients with functional gastrointestinal disorders who are ASCA-positive

Exclusion Criteria:

* Patients with symptoms such as a 10% weight loss within 3 months, abdominal pain, hematochezia, or diarrhea will undergo colonoscopy, and those diagnosed with Inflammatory Bowel Disease will be excluded.
* Treatment history of Diabetes Mellitus, Irritable Bowel Syndrome, or colon cancer.

Where it's running

• Seoul National University Hospital
  Seoul, South Korea Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.