Fetal Growth Restriction: A Case-Control Look at Hormones and Placental Markers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares pregnant individuals with idiopathic fetal growth restriction to appropriate controls to explore potential biological factors. Researchers will examine maternal serum progesterone and placental expression of HMOX-1, along with a marker of placental blood vessel growth. The goal is to identify associations that might explain why some pregnancies experience restricted fetal growth without obvious causes. Inclusion is limited to singleton pregnancies dated by gestational age, while excluding known fetal anomalies and certain treatments or conditions. The study is conducted at a university hospital in Kuala Lumpur, Malaysia, led by National University of Malaysia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* singleton
* dated pregnancy

Exclusion Criteria:

* fetus with structural or chromosomal anomaly
* receive treatments such as aspirin, progestogen, low molecular weight heparin
* has pre-existing medical disorders such as autoimmune disease, hypertension, diabetes
* smoking
* suspected intrauterine infection

Where it's running

• Hospital Canselor Tuanku Muhriz
  Kuala Lumpur, Malaysia Recruiting
• Hospital Canselor Tuanku Muhriz
  Kuala Lumpur, Kuala Lumpur, Malaysia Not yet recruiting

Study contacts

• Study coordinator: Rahana Abd Rahman, MOG (UKM)
• Email: drrahana@hctm.ukm.edu.my
• Phone: +60122719985

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Fetal Heart Function in Growth-Restricted Pregnancies

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• Combined first-trimester screening for pregnancy complications

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• Left-side positioning for pregnancies with fetal growth restriction

  This trial tests whether pregnant people with fetal growth restriction who lie on their left side for several hours a day help their baby grow better and affect maternal and fetal health measures.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT06919692

• Examining placental blood flow using contrast ultrasound in pregnancies with growth restriction

  This study is testing how well blood flows in the placenta of women having a medical termination of pregnancy, comparing those with and without fetal growth restriction to learn more about these conditions.

  Recruiting Phase 3 Central Hospital, Nancy, France · Nancy · NCT06497959

• L-citrulline supplementation during pregnancy to reduce adverse birth outcomes in Kenyan women at risk of malaria.

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  Recruiting Liverpool School of Tropical Medicine · Kisumu · NCT05934318

• Comparing two methods for inducing labor in pregnancies with fetal growth restriction

  This study is testing whether using a balloon to help start labor is better than using medication for women with babies that aren't growing well, to see if it leads to fewer C-sections and healthier babies.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT05674487

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.