Examining placental blood flow using contrast ultrasound in pregnancies with growth restriction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate placental vascularization in women undergoing medical termination of pregnancy, comparing those with fetal growth restriction to those without. It employs contrast-enhanced ultrasound (SonoVue) to assess placental blood flow and function in vivo, which is crucial for understanding the pathophysiology of conditions like preeclampsia and intrauterine growth restriction. The study will include 30 women over a 48-month period at the CHRU de Nancy, focusing on the differences in placental perfusion between the two groups. This approach seeks to provide insights that could lead to better management of pregnancies affected by these complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult woman (age ≥18 years),
* Gestational age between 16 GW + 0 days and 38 GW + 6 days,
* Singleton pregnancy,
* Whose request of a medical termination of pregnancy (IMG) has been formulated and accepted in a written form by the Centre Pluridisciplinaire de Diagnostic Prénatal (CPDPN) of the Centre Hospitalier Régional Universaitaire (CHRU) de Nancy,
* Affiliated to the social security system or benefit from such a system,
* Having received full information and having signed an informed consent form.

Criteria specific to patients in the "growth restriction" group:

\- Severe growth restriction defined by an estimation of foetal weight below the 3rd percentile using ultrasound performed no more than 15 days prior to the IMG (the diagnosis must be established at the time of the request for IMG in routine care).

Exclusion Criteria:

* Person who do not speak French
* Any medical condition contraindicating the administration of SonoVue, in particular:

  * Hypersensitivity to sulfur hexafluoride or to one of the other components of SonoVue® such as polyethylene glycol (PEG),
  * Women with recent acute coronary syndrome or unstable ischaemic heart disease,
  * Women with a right-to-left shunt, severe pulmonary arterial hypertension (pulmonary arterial pressure \> 90 mmHg), uncontrolled systemic hypertension and women suffering from respiratory distress syndrome.
* Persons covered by articles L. 1121-5, L. 1121-7 and L1121-8 of the French Public Health Code:

  * Breast-feeding mother
  * Minor (not emancipated)
  * An adult subject to a legal protection (guardianship, curatorship, safeguard of justice)
  * An adult unable to give consent
* Persons deprived of their liberty by a judicial or administrative decision, persons under psychiatric care by virtue of articles L. 3212-1 and L. 3213-1

Where it's running

• CHRU de NANCY
  Nancy, France Recruiting

Study contacts

• Study coordinator: Matthieu DAP, Doctor
• Email: m.dap@chru-nancy.fr
• Phone: +333 83 34 36 11

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Left-side positioning for pregnancies with fetal growth restriction

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• Comparing two methods for inducing labor in pregnancies with fetal growth restriction

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• Using echocardiography to diagnose fetal growth issues in twin pregnancies

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  Recruiting University Hospital, Ghent · Ghent and 2 other locations · NCT05423665

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.