Improving mapping techniques for heart rhythm disorder treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on enhancing the identification of diseased heart areas responsible for ventricular tachycardia (VT) episodes in patients with structural heart disease. It utilizes a novel method called Optimised Decrement Evoked Potential (DeEP) mapping to guide catheter ablation, a minimally-invasive procedure aimed at preventing VT recurrence. By improving the mapping techniques, the study seeks to increase the effectiveness of ablation procedures, which currently face challenges in accurately locating the problematic areas in the heart. The study involves patients who have implantable cardiac defibrillators and are eligible for VT ablation as part of their standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥18 years old
* Patients with cardiac implantable electronic devices (CIED) (e.g. pacemakers, cardiac resynchronisation therapy (CRT) devices, implantable cardioverter defibrillator (ICD) devices)
* Eligible for VT ablation as part of standard care (urgent or elective)
* Ischaemic heart disease and prior myocardial infarction (MI) (using the international definition of MI: Q waves or imaging evidence of regional myocardial akinesis/thinning in the absence of a non-ischemic cause with documentation of prior ischaemic injury) OR other structural heart disease (such as: arrhythmogenic cardiomyopathy (ACM), or dilated cardiomyopathy (DCM), or hypertrophic cardiomyopathy (HCM), or sarcoidosis, or myocarditis).
* Catheter ablation of VT ablation using Abbott intracardiac mapping catheter and Ensite intracardiac mapping system.

Exclusion Criteria:

* Lacks capacity to provide informed consent
* New York Heart Association (NYHA) class IV heart failure
* Life expectancy of less than 12 months
* Implanted with a ventricular assist device
* Presence of mobile intracardiac thrombus
* Reversible cause of VT
* Women who are pregnant or nursing
* Both mechanical aortic and mitral valves
* Enrolment in a concurrent interventional clinical study that in the judgement of the investigator would increase risk to the patient or deem the patient inappropriate to participate in this study.

Where it's running

• University Hospitals Coventry & Warwickshire NHS Trust
  Coventry, West Midlands, United Kingdom Recruiting

Study contacts

• Study coordinator: Shivam Joshi
• Email: optodeepstudyoffice@uhcw.nhs.uk
• Phone: +442476966907

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Ventricular Tachycardia in Structural Heart Disease: A Registry

  This registry will track adults with structural heart disease who have VT or treated nonsustained VT to see how they are managed and what happens over time in real-world care in China.

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• Registry to evaluate catheter-assisted procedures for structural heart disease

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  Recruiting University of Luebeck · Lübeck, Schleswig-Holstein · NCT06977139

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• Prognosis prediction for patients with cardiovascular and cerebrovascular diseases using multi-omics

  This study is trying to find out how different biological factors affect people with heart and brain blood vessel diseases to help doctors predict outcomes and personalize treatments for them.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT06001073

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.