Measuring how the right ventricle and pulmonary artery work together in valve disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll adults with significant structural valve disease (severe secondary mitral regurgitation, at least severe tricuspid regurgitation, or significant pulmonary valve disease) at CHU Nantes. Participants will undergo invasive right-heart hemodynamic assessment using conductance catheters—the gold standard for RV physiology—alongside standard non-invasive imaging. Researchers will compare invasive RV–PA coupling measures with imaging-derived indices such as TAPSE/PASP and RV strain to quantify correlations. The goal is to identify accurate imaging surrogates that could support clinical decision-making in valvular heart disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥ 18 years old);
* Patients with severe structural heart disease (meeting at least one of the following three criteria):

  * Heart failure with moderate-to-severe or severe secondary mitral regurgitation
  * At least severe tricuspid regurgitation
  * Significant pulmonary valve stenosis and/or regurgitation

Exclusion Criteria:

* Patients under legal guardianship or protection (e.g., guardianship, trusteeship, or any other legal protection measure);
* Pregnant or breastfeeding women;
* Vulnerable individuals (e.g., persons deprived of liberty, adults under legal protection);
* Contraindication to right heart catheterization, including:

  * Known proximal venous occlusion of the superior or inferior vena cava territory
  * Presence of a mobile mass in the right heart chambers
  * Significant tricuspid stenosis

Where it's running

• CHU of NANTES
  Nantes, Loire Atlantique, France Recruiting

Study contacts

• Principal investigator: Robin LE RUZ, MD, PhD — Hospital of Nantes
• Study coordinator: Robin LE RUZ, MD, PhD
• Email: robin.leruz@chu-nantes.fr
• Phone: 02. 53.48.28.36

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.