Clinical trial Recruiting at 12 sites Phase 4 Interventional Ages 18 and up

Comparing two diabetes medications, empagliflozin and dapagliflozin

Official title: A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record

Run by Herlev and Gentofte Hospital · NCT06642272 · Data updated 2026-11-12

This study is testing which diabetes medication, empagliflozin or dapagliflozin, works better for people with type 2 diabetes, chronic kidney disease, and heart failure.

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Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment17200 (estimated)
SponsorHerlev and Gentofte Hospital
Academic / other
Locations12 sites (Copenhagen and 11 other locations)
StatusRecruiting
StartedOctober 10, 2024
Main results expectedDecember 31, 2028
Study endsDecember 31, 2028
Registry record updatedSeptember 18, 2026
Trial IDNCT06642272 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 years or older who are being prescribed empagliflozin or dapagliflozin.

Probably not a fit

Patients who are unable to provide informed consent or who withdraw consent will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of empagliflozin and dapagliflozin in treating patients with type 2 diabetes, chronic kidney disease, and heart failure. Patients who are prescribed either medication as part of their routine care will be included, with treatment assignments randomized through electronic health record systems based on the time of day. This pragmatic approach allows for real-world data collection and analysis of outcomes in a clinical setting.

Why it matters

Potential benefit: If successful, this study could help identify which medication is more effective for patients with diabetes and related conditions, leading to improved treatment strategies.

How similar studies have gone: Other studies have explored the effectiveness of these medications, but this specific approach using electronic health records for cluster randomization is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults aged 18 years or more

Exclusion Criteria:

* Incapabability of giving informed consent
* Withdrawal of informed consent

Where it's running

  • Bispebjerg Hospital
    Copenhagen, Denmark
    Recruiting
  • Rigshospitalet
    Copenhagen, Denmark
    Recruiting
  • Herlev and Gentofte Hospital
    Herlev, Denmark
    Recruiting
  • Steno Diabetes Center Copenhagen
    Herlev, Denmark
    Recruiting
  • Nordsjællands Hospital
    Hillerød, Denmark
    Recruiting
  • Holbæk Sygehus
    Holbæk, Denmark
    Recruiting
Show 6 more locations
  • Hvidovre Hospital
    Hvidovre, Denmark
    Recruiting
  • Sjællands Universitetshospital
    Køge, Denmark
    Recruiting
  • Nykøbing F. Sygehus
    Nykøbing Falster, Denmark
    Recruiting
  • Sjællands Universitetshospital
    Roskilde, Denmark
    Recruiting
  • Bornholms Hospital
    Rønne, Denmark
    Recruiting
  • Slagelse Sygehus
    Slagelse, Denmark
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.