Comparing two diabetes medications, empagliflozin and dapagliflozin
Official title: A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record
Run by Herlev and Gentofte Hospital · NCT06642272 · Data updated 2026-11-12
This study is testing which diabetes medication, empagliflozin or dapagliflozin, works better for people with type 2 diabetes, chronic kidney disease, and heart failure.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 17200 (estimated) |
| Sponsor | Herlev and Gentofte Hospital Academic / other |
| Locations | 12 sites (Copenhagen and 11 other locations) |
| Status | Recruiting |
| Started | October 10, 2024 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | September 18, 2026 |
| Trial ID | NCT06642272 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 years or older who are being prescribed empagliflozin or dapagliflozin.
✕Probably not a fit
Patients who are unable to provide informed consent or who withdraw consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare the effectiveness of empagliflozin and dapagliflozin in treating patients with type 2 diabetes, chronic kidney disease, and heart failure. Patients who are prescribed either medication as part of their routine care will be included, with treatment assignments randomized through electronic health record systems based on the time of day. This pragmatic approach allows for real-world data collection and analysis of outcomes in a clinical setting.
Why it matters
Potential benefit: If successful, this study could help identify which medication is more effective for patients with diabetes and related conditions, leading to improved treatment strategies.
How similar studies have gone: Other studies have explored the effectiveness of these medications, but this specific approach using electronic health records for cluster randomization is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years or more Exclusion Criteria: * Incapabability of giving informed consent * Withdrawal of informed consent
Where it's running
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Bispebjerg Hospital
Copenhagen, Denmark Recruiting -
Rigshospitalet
Copenhagen, Denmark Recruiting -
Herlev and Gentofte Hospital
Herlev, Denmark Recruiting -
Steno Diabetes Center Copenhagen
Herlev, Denmark Recruiting -
Nordsjællands Hospital
Hillerød, Denmark Recruiting -
Holbæk Sygehus
Holbæk, Denmark Recruiting
Show 6 more locations
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Hvidovre Hospital
Hvidovre, Denmark Recruiting -
Sjællands Universitetshospital
Køge, Denmark Recruiting -
Nykøbing F. Sygehus
Nykøbing Falster, Denmark Recruiting -
Sjællands Universitetshospital
Roskilde, Denmark Recruiting -
Bornholms Hospital
Rønne, Denmark Recruiting -
Slagelse Sygehus
Slagelse, Denmark Recruiting
Study contacts
- Study coordinator: Morten Schou, Professor
- Email: morten.schou.04@regionh.dk
- Phone: 004540523920
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study looks at the challenges and support African American adults with kidney disease and diabetes face to see how it affects their health and how to help them take better care of themselves.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.