Exploring biomarkers and lung damage in ARDS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the occurrence of barotrauma in patients with Acute Respiratory Distress Syndrome (ARDS), particularly focusing on those with COVID-19. It aims to validate the Macklin effect as a predictor of barotrauma and to analyze inflammatory profiles through blood and bronchoalveolar fluid collection. The study will also utilize chest CT scans to assess lung composition and develop a management algorithm tailored for ARDS patients at high risk of barotrauma. By identifying high-risk features early, the study seeks to improve individualized patient management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical and radiological signs of ARDS, according to Berlin criteria, requiring ICU admission;
* Obtain duly signed informed consent
* Availability of at least one chest CT scan during hospital stay

Exclusion Criteria:

• Poor quality imaging (because of motion/respiratory artefacts).

Where it's running

• IRCCS San Raffaele Scientific Institute
  Milan, Italy Recruiting
• A.O.U. di Cagliari
  Cagliari, Italy Not yet recruiting
• A.O.U. Pisana
  Pisa, Italy Not yet recruiting
• Ospedale San Carlo
  Potenza, Italy Not yet recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using imaging to assess risk of lung injury in ARDS patients

  This study is testing if using advanced imaging can help doctors spot lung problems early in patients with acute respiratory distress syndrome (ARDS) to better manage their care.

  Recruiting at 2 sites Università Vita-Salute San Raffaele · Catanzaro, Calabria and 1 other locations · NCT05816954

• Full-Course ECMO Pathway for Moderate-to-Severe ARDS

  This study tests a standardized, full-course ECMO management pathway to see if it improves care for adults with moderate-to-severe ARDS treated with VV-ECMO in real-world Chinese centers.

  Recruiting at 15 sites Southeast University, China · Beijing and 38 other locations · NCT07726953

• Height measurement methods to guide ventilator settings in ARDS

  We’re testing whether more precise height measurements change how researchers set lung-protective tidal volumes in adults with ARDS who are on a ventilator.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07595926

• Corticosteroids for a hyperinflammatory state in critical illness

  This trial tests whether methylprednisolone helps improve organ function and survival in adults with sepsis or ARDS who show a hyperinflammatory profile.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07511582

• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

  This project will follow adults with ARDS on mechanical ventilation to see how positive‑pressure breathing affects the right heart over time and how that relates to circulation.

  Recruiting Bicetre Hospital · Le Kremlin-Bicêtre · NCT07450846

• Umbilical‑cord mesenchymal stem cell and secretome therapy for severe ARDS

  This trial tests whether IV umbilical‑cord mesenchymal stem cells, alone or with secretome, help adults with severe ARDS recover lung function and reduce inflammation.

  Recruiting Phase 1/2 PT. Prodia Stem Cell Indonesia · Jakarta Pusat, DKI Jakarta · NCT07439848

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.