Lifestyle for Brain Health — Time-Restricted Eating and Mindfulness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized two-arm, 9-month intervention comparing mindfulness yoga plus time-restricted eating and nutritional counseling against cognitive training plus stretching in older adults at increased risk for Alzheimer disease. Primary and secondary outcomes include cognitive performance, plasma pTau217 as a marker of neurodegeneration, measures of physical fitness, and metabolic health. The protocol is harmonized with a parallel LIBRA-NET study at Slovak sites so that data from the cognitive-training/stretching arm and some clinical parameters are pooled for joint analysis. The combined approach tests whether lifestyle changes can modify both clinical and biomarker indicators of early neurodegeneration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 60-80 years
* Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI)
* mini-mental-scale (MMSE) score between 24-30
* Positive plasma pTau217 biomarker
* Stable dose of iAChE therapy (if applicable)
* Ability to participate in a 9-month intervention

Exclusion Criteria:

* Stroke or myocardial infarction within the past year
* Decompensated internal conditions (e.g., severe heart failure, kidney failure, unstable diabetes, GLP1 agonist therapy)
* Long-term psychiatric treatment (except well-managed depression)
* Neurological conditions affecting mobility or cognition (e.g., Parkinson's disease, severe tremor, epilepsy)
* Severe sensory or motor impairment preventing protocol participation
* Active cancer treated within the past 5 years
* Poor anticipated compliance (e.g., transport issues, time constraints, non-cooperation)
* Concurrent participation in another clinical study
* Unstable iAChE medication regimen
* Substance or alcohol dependence

Where it's running

• Fnusa/ Icrc
  Brno, Czechia Recruiting

Study contacts

• Principal investigator: Kateřina Sheardova, MD. PhD. — The International Clinical Research Center of St. Anne's University Hospital in Brno (FNUSA-ICRC)

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.