Nutrition and exercise program for brain health in older adults
Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention, LIBRA-NET
NA · Slovak Academy of Sciences · NCT06986096
This study tests whether a 9-month program of exercise and nutrition can help improve brain health and physical function in older adults at risk for Alzheimer's disease.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | Slovak Academy of Sciences (other gov) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Bratislava, Bratislava Region) |
| Trial ID | NCT06986096 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of a 9-month intervention combining aerobic-strength training and nutritional counseling on cognitive and motor functions in older adults at risk for Alzheimer's disease. Participants will be compared to a control group receiving cognitive training and stretching. The goal is to determine how these lifestyle changes impact brain health, metabolism, and markers of neurodegeneration. The study focuses on non-pharmacological approaches to address the increasing incidence of dementia.
Who should consider this trial
Good fit: Ideal candidates are non-smoking older adults with subjective or mild cognitive impairment and elevated biomarkers indicating Alzheimer's disease.
Not a fit: Patients with severe cardiovascular, liver, or kidney diseases, or those with significant comorbidities that prevent participation in the training program may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could improve cognitive function and overall brain health in older adults at risk for Alzheimer's disease.
How similar studies have performed: Other studies have shown promise in using lifestyle interventions for cognitive health, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Non-smokers * Signed informed consent * Presence of subjective or mild cognitive impairment (SCI/aMCI) * Elevated levels of selected biomarkers confirming the presence of a pathological process characteristic of Alzheimer's disease * Absence of any psychological, sociological, or geographical factors that could jeopardize participation in the project. Exclusion Criteria: * Presence of severe cardiovascular, liver, or kidney diseases; advanced or poorly controlled diabetes mellitus (HbA1c \>7%), treated with insulin or incretin analogs; cancer or any other severe disease as assessed by the responsible physician. A history of cancer treated with chemotherapy or radiotherapy if within less than 5 years post-treatment. * Lack of cooperation, inflexible schedule, or problematic transportation. * Insufficient functional capacity or presence of comorbidities that prevent participation in the training program (assessment by an internist, cardiologist, neurologist, orthopedic specialist, or other relevant specialists). * Presence of a pacemaker or any metal implants (contraindication for MRI examination), or allergy to local anesthetics (contraindication for muscle biopsy). * Smoking, alcohol dependence, or addiction to other narcotic substances. * Stroke or myocardial infarction within the last year. * Long-term treatment for psychiatric disorders - a depressive syndrome is not an exclusion criterion if it is compensated by therapy. * Other diseases of the musculoskeletal or nervous system that potentially interfere with the ability to exercise or cognition - such as severe arthritis, Parkinson's disease, significant essential tremor, epilepsy, etc. * Concurrent participation in another clinical study. * Therapy with cholinesterase inhibitors unless the patient is on a stable dose.
Where this trial is running
Bratislava, Bratislava Region
- Biomedical Research Center Slovak Academy of Sciences — Bratislava, Bratislava Region, Slovakia (RECRUITING)
Study contacts
- Principal investigator: Barbora Ukropcova, Prof. — Biomedical Research Center Slovak Academy of Science
- Study coordinator: Barbora Ukropcova, Prof.
- Email: barbara.ukropcova@sabva.sk
- Phone: +421911643630
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aging, Alzheimer Disease, Life Style, Healthy, Exercise, Cognitive Impairment