Nutrition and exercise program for brain health in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of a 9-month intervention combining aerobic-strength training and nutritional counseling on cognitive and motor functions in older adults at risk for Alzheimer's disease. Participants will be compared to a control group receiving cognitive training and stretching. The goal is to determine how these lifestyle changes impact brain health, metabolism, and markers of neurodegeneration. The study focuses on non-pharmacological approaches to address the increasing incidence of dementia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Non-smokers
* Signed informed consent
* Presence of subjective or mild cognitive impairment (SCI/aMCI)
* Elevated levels of selected biomarkers confirming the presence of a pathological process characteristic of Alzheimer's disease
* Absence of any psychological, sociological, or geographical factors that could jeopardize participation in the project.

Exclusion Criteria:

* Presence of severe cardiovascular, liver, or kidney diseases; advanced or poorly controlled diabetes mellitus (HbA1c \>7%), treated with insulin or incretin analogs; cancer or any other severe disease as assessed by the responsible physician. A history of cancer treated with chemotherapy or radiotherapy if within less than 5 years post-treatment.
* Lack of cooperation, inflexible schedule, or problematic transportation.
* Insufficient functional capacity or presence of comorbidities that prevent participation in the training program (assessment by an internist, cardiologist, neurologist, orthopedic specialist, or other relevant specialists).
* Presence of a pacemaker or any metal implants (contraindication for MRI examination), or allergy to local anesthetics (contraindication for muscle biopsy).
* Smoking, alcohol dependence, or addiction to other narcotic substances.
* Stroke or myocardial infarction within the last year.
* Long-term treatment for psychiatric disorders - a depressive syndrome is not an exclusion criterion if it is compensated by therapy.
* Other diseases of the musculoskeletal or nervous system that potentially interfere with the ability to exercise or cognition - such as severe arthritis, Parkinson's disease, significant essential tremor, epilepsy, etc.
* Concurrent participation in another clinical study.
* Therapy with cholinesterase inhibitors unless the patient is on a stable dose.

Where it's running

• Biomedical Research Center Slovak Academy of Sciences
  Bratislava, Bratislava Region, Slovakia Recruiting

Study contacts

• Principal investigator: Barbora Ukropcova, Prof. — Biomedical Research Center Slovak Academy of Science
• Study coordinator: Barbora Ukropcova, Prof.
• Email: barbara.ukropcova@sabva.sk
• Phone: +421911643630

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.