Evaluating seizures in patients with brain tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on individuals aged 8 and older who have brain tumors associated with seizures, known as tumor-related epilepsy. The research aims to evaluate the natural history of this condition and the impact of surgical treatment on seizure outcomes. Participants will undergo a thorough medical evaluation, including neurological exams and cognitive assessments, to gather data on their condition before and after surgery. The study also seeks to explore the relationship between tumor characteristics, surgical resection, and changes in seizure activity and cognitive function.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

To be eligible for entry into the study, a candidate must meet all the following criteria:

* Be 8 years of age or older.
* Have solitary primary or recurrent brain tumor with associated seizures. Brain tumor may be diagnosed radiologically. Associated seizures are defined as those with activity starting within three months of radiologic diagnosis of the primary or recurrent tumor. In cases when the timing of seizure activity is unclear with respect to the timing of diagnosis, seizures will be considered associated with the tumor if seizure semiology is consistent with that location. Ongoing seizures are not required. Patients can be included if they have had a single previous seizure. Patients who have not experienced seizures after institution of anti-convulsant therapy are not excluded.

EXCLUSION CRITERIA:

Candidates will be excluded if they:

-At the time of enrollment, lack consent capacity due to cognitive impairment that would make them incapable of understanding the explanation of the procedures in this study. Cognitive capacity to consent will be determined at the time of enrollment. Patients with mental disorders or those patients who are cognitively impaired yet still retain consent capacity will not be excluded. Children may be enrolled if there is a parent or guardian able to consent on their behalf.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Kareem A Zaghloul, M.D. — National Institute of Neurological Disorders and Stroke (NINDS)
• Study coordinator: Gretchen C Scott, R.N.
• Email: SNBrecruiting@nih.gov
• Phone: (301) 496-2921

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.