Evaluating residual embolism using advanced imaging techniques
Official title: Residual Embolism Evaluated With Single Photon Emission Computed Tomography - The RESPECT Cohort
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT06473610 · Data updated 2026-11-12
This study is testing new imaging techniques to see if they can better measure leftover blood clots in the lungs of patients with chronic blood vessel blockages.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 358 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Status | Recruiting |
| Started | June 27, 2024 |
| Main results expected | April 2026 |
| Study ends | April 2026 |
| Registry record updated | August 7, 2025 |
| Trial ID | NCT06473610 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients referred for V/Q pulmonary SPECT-CT assessment due to suspected pulmonary hypertension or ongoing symptoms after a pulmonary embolism.
✕Probably not a fit
Patients who are pregnant or those being evaluated for acute pulmonary embolism will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the effectiveness of various single photon emission computed tomography (SPECT) protocols in quantifying residual pulmonary vascular obstruction (RPVO) in patients with chronic thrombo-embolic disease. It compares the performance of SPECT against the traditional planar ventilation/perfusion scintigraphy to better evaluate RPVO. Patients suspected of having pulmonary hypertension or experiencing persistent dyspnea after pulmonary embolism will be included, and the study will take place at the Centre Hospitalier Universitaire de Saint Etienne.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy for patients with chronic thrombo-embolic disease, facilitating better management of their condition.
How similar studies have gone: Other studies have shown promising results using SPECT imaging for similar evaluations, indicating that this approach is supported by existing research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient addressed to nuclear medicine department of Saint-Etienne public hospital for V/Q pulmonary SPECT-CT assess to rule out perfusion obstruction, admitted for a suspicion of pulmonary hypertension (PH), or a persistent dyspnea after PE * Patient affiliated ou beneficiary of social security. Exclusion Criteria: * Pregnant patient. * Patient addressed to nuclear medicine department for acute pulmonary embolism. * Impossibility of the entire protocol acquisitions realization.
Where it's running
-
Centre Hospitalier Universitaire
Saint-Etienne, France Recruiting
Study contacts
- Principal investigator: Pierre-Benoit BONNEFOY, MD — Centre Hospitalier de Saint-Etienne
- Study coordinator: Pierre-Benoit BONNEFOY, MD
- Email: pierre-benoit.bonnefoy@chu-st-etienne.fr
- Phone: (0)4 77 82 94 43
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.