Sensory neuronopathy: finding the best disease scales for tracking progression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study monitors changes in clinical assessment scores over time in people with sensory neuronopathy to identify the most suitable tool for tracking progression. The goal is to determine a SN-specific or SN-appropriate scale that can reliably reflect disability and treatment response. Participants are adults diagnosed with probable SN and followed across several centers in France to compare available scales. The study emphasizes longitudinal scoring rather than a new drug intervention. No biomarker validation is described, focusing instead on scale performance and feasibility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient affiliated with or beneficiary of a social security system
* Patient having received appropriate study information
* Adult patient ≥18 years old, male or female
* Patient diagnosed with probable SN according to Camdessanché et al. diagnostic criteria
* SN with one of the following etiologies:

Paraneoplastic SN with anti-Hu or anti-CV2/CRMP5 antibodies SN associated with Sjögren's syndrome, systemic lupus erythematosus, or primary biliary cholangitis Platinum-salt-induced SN SN caused by CANVAS syndrome

Exclusion Criteria:

* Patient unable to understand or read French
* Patient refusal to participate
* Patient known to have another neuropathy phenotype and/or etiology that could significantly influence clinical scales and electrophysiological parameters, including:

  * Diabetes mellitus
  * Significant alcohol consumption
  * Severe chronic kidney disease (GFR \<30 ml/min)
  * Vitamin B12 and/or vitamin E deficiency
  * Vitamin B6 excess
  * Chemotherapy other than platinum salts
  * HIV infection

Where it's running

• Chu de Saint-Etienne
  Saint-Etienne, France Recruiting
• Chu D Angers
  Angers, France Not yet recruiting
• Chu de Clermont Ferrand
  Clermont-Ferrand, France Not yet recruiting
• Chu de Grenoble
  Grenoble, France Not yet recruiting
• Chu de Lille
  Lille, France Not yet recruiting
• Chu de Limoges
  Limoges, France Not yet recruiting

Study contacts

• Study coordinator: Jean philippe PHD CAMDESSANCHE
• Email: j.philippe.camdessanche@chu-st-etienne.fr
• Phone: +33 4 77 12 05 59

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.