Remediation of memory impairments using motor encoding and dynamic imagery in Alzheimer’s disease
Official title: Validation of a Remediation Method for Memory Impairments Through Motor Encoding in Patients With Alzheimer's Disease
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT07632755 · Data updated 2026-11-12
This trial tests whether combining real action, motor imagery, and dynamic video cues can help memory in people with early Alzheimer’s disease and compares it to a control group without Alzheimer’s.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 3 sites (Grenoble and 2 other locations) |
| Status | Recruiting |
| Started | July 15, 2026 |
| Main results expected | March 2028 |
| Study ends | June 2028 |
| Registry record updated | July 31, 2026 |
| Trial ID | NCT07632755 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 60+ who are in the early stage of Alzheimer's disease with mild memory impairment and MMSE of 21 or higher, and who can participate in a French-language program.
✕Probably not a fit
Patients with advanced dementia, significant sensory or motor impairments, or unwillingness to participate may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In France, this study investigates a non-pharmacological approach to support memory by linking motor activity with encoding and using videos to reduce cognitive load. Participants with early-stage Alzheimer’s disease and a non-AD control group will engage in three conditions: action execution, motor imagery, and a control condition, to see which most improves recall. The study aims to validate a library of 120 daily-activity videos and assess whether video support and motor engagement enhance memory performance. Outcomes may inform digital tools, like serious games, to boost autonomy in daily living for older adults. Enrollment targets adults 60+ who are French-speaking and meet specific inclusion criteria, excluding those with significant sensory, language, or motor impairments.
Why it matters
Potential benefit: If successful, patients may experience better memory performance and greater independence in daily activities.
How similar studies have gone: Previous non-pharmacological approaches to memory have shown potential, and this study extends those concepts with motor engagement and dynamic visuals, representing a novel combination.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patient group: Diagnosis of Alzheimer's disease made by one of the consulting physicians-a neurologist and/or geriatrician (Dubois et al., 2014)-at the early stage, presenting with mild memory impairment of which the patient has been informed \- MMSE score of 21 or higher Control group: individuals without a diagnosis of Alzheimer's disease, but meeting the other criteria listed below * Enrollment in a social security program * Age 60 or older * French as a native language * Consent to participate Exclusion Criteria: * Uncorrected visual or hearing impairments * Language or motor impairments * Delirium or psychosis. * Medical treatment affecting vision, language, or motor skills (or participation in a study involving a drug or device that influences cognition). * Refusal to participate. * Inability to communicate * Persons deprived of liberty by a judicial or administrative decision and adults subject to a legal protection measure or unable to express their consent
Where it's running
-
Chu de Saint Etienne
Saint-Etienne, France Recruiting -
Chu Grenoble
Grenoble, France Not yet recruiting -
HLC, Hôpital des Charpennes
Villeurbanne, France Not yet recruiting
Study contacts
- Study coordinator: Céline BORD, MD
- Email: celine.borg@chu-st-etienne.fr
- Phone: (0)4 77 82 88 82
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.