Evaluating brain blood flow using contrast-enhanced ultrasound
Official title: Quantification of Cerebral Perfusion at the Patient's Bedside When Performing Contrast-enhanced Ultrasound in Neurointensive Care Patients
Run by Assistance Publique - Hôpitaux de Paris · NCT05893407 · Data updated 2026-11-12
This study is testing a new ultrasound method to see if it can help doctors check blood flow in the brains of patients with recent brain injuries.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | July 21, 2023 |
| Main results expected | July 2025 |
| Study ends | July 2025 |
| Registry record updated | June 19, 2025 |
| Trial ID | NCT05893407 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older who are admitted to the intensive care unit for acute brain injuries confirmed by CT or MRI.
✕Probably not a fit
Patients who are pregnant or have contraindications to the contrast agent used in the study will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to assess brain tissue perfusion in patients with acute brain injuries using contrast-enhanced ultrasound perfusion imaging (PerCEUS). It focuses on diagnosing brain tissue hypoperfusion by evaluating the heterogeneity of brain perfusion and correlating the results with standard multimodal monitoring techniques. The PerCEUS measurements will be performed at the bedside by a physician shortly after hospitalization, with data analyzed offline using specialized software. The study will involve selecting specific regions of interest in the brain to assess perfusion levels.
Why it matters
Potential benefit: If successful, this study could improve the diagnosis and management of acute brain injuries by providing real-time insights into brain perfusion.
How similar studies have gone: While the use of contrast-enhanced ultrasound for brain perfusion assessment is gaining interest, this specific approach is relatively novel and has not been extensively tested in similar studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 * Intensive care unit admission for acute brain injury * Proven acute brain injury by CT and/or MRI * Requiring a contrast ultrasound imaging * Informed consent of patient or relative Exclusion Criteria: * Pregnancy * Not sufficient temporal window * Contraindications to Sonovue ® : acute coronary syndromes, severe ischemic heart disease (requiring revascularization), pulmonary arterial hypertension \> 90 mmHg, right-left shunt, ARDS, dobutamine's use, known allergy or adverse reaction to Sonovue® * Patient on State Medical Assistance
Where it's running
-
Lariboisière Hospital
Paris, France Recruiting
Study contacts
- Principal investigator: Romain BARTHELEMY, MD — AP-HP Lariboisière Hospital, Department of Anaesthesia and Intensive Care
- Study coordinator: Romain BARTHELEMY, MD
- Email: romain.barthelemy@aphp.fr
- Phone: +33 (0)1 49 95 85 15
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.