Evaluating a new olfactory training device for post-viral smell loss

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to assess the effectiveness of a modified olfactory training device in treating patients with post-viral olfactory dysfunction. It will compare the modified device's efficacy against a conventional olfactory training device over a 12-week intervention period. The study will utilize a randomized, controlled, multi-center approach, measuring changes in olfactory ability using the Sniffer Stick Test and other secondary endpoints related to olfactory function and brain activity. The findings will help understand the mechanisms behind olfactory training in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18-80 years old, gender not limited.
2. Patients diagnosed with olfactory dysfunction following infections of the upper respiratory tract, as determined by Sniffin' Sticks test (including TDI value test).
3. Voluntarily signs the informed consent form.

Exclusion Criteria:

1. Patients with post-traumatic olfactory dysfunction, rhinosinusitis-related dysfunction and olfactory dysfunction caused by other reasons.
2. Patients with concomitant sinonasal disease.
3. Patients with chronic diseases, such as hypertension, diabetes, bronchopneumonia, chronic obstructive pulmonary disease, etc.
4. Patients with serious coexisting diseases: such as malignant tumors, etc., with a life expectancy of less than 2 years.
5. Patients who cannot tolerate olfactory function testing and treatment.
6. Patients who have taken oral glucocorticoids, antibacterial drugs, anti-leukotrienes, antihistamines, or received olfactory training within four weeks will be excluded.
7. Patients who are receiving treatment that affects olfactory recovery.
8. Patients with smoking habits.
9. Patients who are already or plan to be pregnant.
10. According to the judgment of the researchers, the patient cannot complete this study or cannot comply with the requirements of this study (such as memory or behavior abnormalities, depression, heavy drinking, previous breach of contract).
11. Patients who did not consent for participating in the study.

Where it's running

• Bejing
  Beijing, China Recruiting

Study contacts

• Study coordinator: Dawei Wu, MD, PhD
• Email: davidwuorl@163.com
• Phone: 13522503401

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• See if smelling tests and guidance improve well-being for people with smell loss

  This study tests whether giving people with smell dysfunction tailored information and guidance after smell testing can improve their mental health and use of care.

  Recruiting Phase 2 Monell Chemical Senses Center · Philadelphia, Pennsylvania · NCT07222891

• Topical PRP vs PRP injection for smell disorders

  This study tests whether topical PRP applied with a carrier or PRP delivered by injection into the nasal area can improve smell in adults with long-standing olfactory dysfunction.

  Recruiting Phase 3 Taipei Veterans General Hospital, Taiwan · Taipei · NCT07151703

• Investigating the effects of endoscopic skull base surgery on smell

  This study tests how endoscopic skull base surgery affects the sense of smell in patients to better understand any smell-related problems that might happen after the surgery.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant and 2 other locations · NCT06874426

• Using a new device to improve sense of smell in older adults

  This study is testing a new device to see if it can help older adults improve their sense of smell and overall well-being.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06733636

• Slow-SPEED UK: A Double-Blind Feasibility Trial for a Digitally Supported Activity Program in Adults 40+ with Smell Loss

  We’re testing whether a smartphone-enabled, wearable-guided activity plan can be safely and practically used by adults 40 and over who have a reduced sense of smell and low activity, to see if people can stick with it and accept it.

  Recruiting Queen Mary University of London · London · NCT06600438

• Investigating olfactory dysfunction after COVID-19 infection

  This study is trying to understand why some people still have trouble smelling after recovering from COVID-19 by looking at samples from their noses.

  Recruiting at 6 sites Universitaire Ziekenhuizen KU Leuven · Brussels, Brussels Capital and 6 other locations · NCT06482138

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.