Topical PRP vs PRP injection for smell disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, Phase 3 trial compares two delivery methods of autologous platelet-rich plasma (PRP) for persistent olfactory dysfunction in adults. Participants receive a single PRP treatment by either intranasal injection or carrier-assisted topical application to the olfactory cleft, followed by three months of daily olfactory training and pre/post smell testing. The study will evaluate changes in olfactory function and patient comfort, along with adverse effects. PRP is prepared on-site to achieve a platelet concentration 2-3 times above baseline. The trial aims to determine which method provides greater efficacy and tolerability in restoring odor function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged between 18 and 80 years, regardless of sex
* Subjective complaint of olfactory dysfunction with confirmed hyposmia or anosmia based on standardized olfactory testing
* History of at least 3 months of prior olfactory training but with persistent olfactory complaints

Exclusion Criteria:

* Congenital anosmia
* Diagnosed neurological or structural brain abnormalities (e.g., brain tumor, major head trauma, stroke) with low likelihood of olfactory recovery
* Inability or unwillingness to comply with study procedures or follow-up assessments

Where it's running

• Taipei Veterans General Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Study coordinator: Dr. Yun-Ting Chao Principal Investigator (Attending Physician and Head of Dep.), PhD
• Email: yunting001@gmail.com
• Phone: 886-2-2875-7337

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.