Dietary nitrate, oral bacteria, and blood pressure in children with primary hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will recruit 10–18-year-old participants with diagnosed primary hypertension and an age- and sex-matched healthy control group at Istanbul University Faculty of Dentistry. All participants will have non-invasive oral and dental exams, saliva sampling for nitrate/nitrite measurements, and oral microbiome profiling to identify nitrate-reducing bacteria. Blood pressure and related clinical data will be collected and compared between groups to look for correlations with salivary nitrite production and microbial composition. The study excludes recent antibiotic or mouthwash use and participants with periodontal disease to reduce confounding of the oral microbiome.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Applied to the Istanbul University Faculty of Medicine, Department of Pediatric Nephrology,
* Between the ages of 10 and 18,
* Diagnosed with primary hypertension,
* Clinically excluded from secondary hypertension or heart failure,
* No systemic or chronic disease other than hypertension,
* No periodontal disease, dental infection, or oral mucosal disease,
* Not taking regular antihypertensive or other medications for a chronic disease,
* Not having received antibiotic treatment in the last 3 months,
* Patients who have not used mouthwash in the last 3 months,
* Have no allergies to nitrate-rich foods,
* Both male and female patients will be included.

Exclusion Criteria:

* Younger than 10 years of age or older than 18 years of age
* Clinically diagnosed with secondary hypertension or heart failure
* Have a systemic disease
* Have periodontal disease, dental infection, or oral mucosal disease
* Are taking regular antihypertensive medications or other chronic illnesses
* Have received antibiotic treatment within the last 3 months
* Have used mouthwash within the last 3 months
* Are allergic to nitrate-rich foods will not be included in the study.

Where it's running

• Istanbul University Faculty of Dentistry
  Istanbul, Fatih, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Yelda Kasimoglu Assoc. Prof.
• Email: yelda.kasimoglu@iu.edu.tr
• Phone: +90 533 623 39 78

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.